ZHANG CLINIC®
PROTOCOLS
Herb Distribution @
www.hepapro.com



Zhang Clinic
20 E. 46th Street
Suite 1402
New York,  NY 10017
Tel: (212) 573-9584 
Fax: (212) 573-6639 

 
This is a password-protected private information web. Materials presented here is only intended for viewing by Zhang Clinic employees, affiliated professional practitioners and clinic patients.
Hepatitis C
 
Lyme Disease
Hepatitis Peripheral Complications Colitis /Crohn's Disease (Inflammatory Bowel Syndrome)
Non-Alcoholic Steatohepatitis (NASH): Fatty Liver Liver Cirrhosis Related Conditions
Alcoholic Liver Disease  
Auto-Immune Hepatitis
Cholestatic Hepatitis
SinoMed Research Home
About Dr. Zhang
Herbs

ZHANG CLINIC featured again in
Dr. Weil's "Self Healing" newsletter

Click here to read the excerpt

Formula List
AI # 3 Capsule
Allicin Capsule
Artemisia Capsule
Artemisia 2 Capsule
(Double Potency)
BM Capsule
ArthralEZ
Capillaris Combination
Circulation P Capsule
Copmine Formula
Coptis Capsule
Cordyceps Capsule
DH-Artemisinin Capsule
Gall Formula 1
Gineseng and Atractylodes Formula
Glycyrrhizin Capsule
GL2
Hepa Formula 1A
Hepa Formula 2
HerbLipido
HerbSom Capsule
HerbZac Capsule
HH Tablets
HH 2 Capsule
(Double Potency)
Ligustrin Capsule
Milk Thistle Plus
MVM Formula
Olivessence Capsule
Puerarin Capsule
R-5081 Capsule
R-OBG Capsule
Schisandra Plus
Sedin
TGP formula
Yunan Baiyao Capsule
 
Allicin Capsules
Recommended Daily Dose:
For prevention, 1 capsule per day. For infections, 2 to 3 capsules, 3 times a day.

(Individual Dosage May Vary. Please Consult Health Care Professional)
 


A.    Original Herb:

Allium sativa Bulb (garlic)

Garlic has a long history of medical applications.   In TCM, it is described as having an acrid taste and a “warm” property.  Traditionally, it is used as a Qi (vital energy) stimulant. In TCM, it is used for infections, diarrhea, dysentery, whooping cough, carbuncle, furuncle, tinea capitis, edema, snakebites, and insect stings. [1]

B.     Chemical Composition:

        Purified allitridi, the precursor of allicin.

 Chemical name: diallyl thiosulfonate (2-propene-1-sulfinothioic acid, S-2-propenyl ester.)
       Molecular structure is: CH2=CHCH2-S=O-SCH2CH=CH2
        
Molecular formula is C6H10OS2 and molecular weight is 162.27 Daltons [2]

Garlic bulb contains volatile oil, of which alliin is the major constituent. When the fresh bulb is macerated, alliin is decomposed into allicin by allinase. Allicin is the characteristic odor of the garlic. Allitridi is a highly purified and concentrated garlic essence and is the precursor of allicin. When it is metabolized in the body, it becomes allicin and displays its characteristic odor and pharmacological actions.

The odor causing agent of of the garlic also contains its anti-infection properties. Scientists in China have been able to isolate the active ingredient of garlic, determined its molecular structure and mass produce the chemically stable form, the allitridi. [3] The Allicin Capsule is made in a time-release form and will keep the concentration of allicin in the blood evenly distributed.

 

C.    Pharmacology:

  1. Anti-Microbial effects

Pharmacological studies showed anti-bacterial, anti-mycobacterium, anti-fungal, anti-protozoa, and anti-viral properties. 

    1. Anti-bacterial effects

A 0.5% aqueous solution of the bulb was lethal to Salmonella typhi within five minutes after contact. It was significantly bacteriostatic or bactericidal against the following: Staphylococci, Neisseria meningitides, Streptococcus pneumonia, Shigelia dysentery, Corynebacterium diphtheriae, Escherichia coli, Salmonella typhi and paratyphi, Mycobacterium tuberculosis, var. hominis, and Vibrio cholerae.  Bacteria resistant to penicillin, streptomycin, chloramphenicol, or chlortetracycline were sensitive to allitridi. The mechanism of the antibacterial action of allitridi involved a combination of its oxygen atom with cysteine to avert the formation of cystine, thus interrupting essential oxidation and reduction reactions in the bacteria. [4,5,6, 7,8]

    1. Anti-fungal effects

Anti fungal action was observed in vitro against Schlemm’s Dermatomyces flavosa, Trichophyton vilaceum, and Candida albicans. In vitro tests proved that 1-125 mcg/ml of diallyl thiosulfonate was inhibitory against Candida albicans as was 0.05-1 mcg/ml to Cryptococcus rubrae and 3.2-12.5 mcg/ml to Cryptococcus. The minimum inhibitory dose of allitridi on fungi was 1mcg/ml; its effect was about the same as that of amphotericin B, but was far less toxic. [9,10,11,12]

    1. Anti-protozoal effects.

The ameba trophozoites soon lost their activity upon direct contact with the 5-15% aqueous suspension of the bulb. Experiments using direct contact and fumigation methods showed that garlic juice killed all Trichomonas organisms in 10-25 minutes, and the volatile components in 90-180 minutes, whereas 0.5% of the bulb filtrate deactivated Trichomonas vaginalis in five minutes. A 0.1% injective preparation of the bulb was lethal to tsutsugarnushi fever, including richettsiasis. [4,13,14]

2.        Anti-neoplastic and other effects

Allitridi has anti-neoplastic effects. It showed anti-mitotic action against the cells of ascites sarcoma MTK-1 in rats and those of Ehrlich ascites carcinoma in mice. [15,16] The fresh garlic bulb fed to C3H/He female mice completely suppressed breast cancer. The active component might be allicin. [17] In ascitic and solid types of liver carcinoma in mice, the garlic oil significantly prolonged the survival period of the animals. Marked inhibitory action was detected against many solid sarcoma in animals after intraperitoneal or intra-tumor injection of the oil at dose of 50 to 100 mg/kg; the inhibition rate was 40-50%. [18] The anti-mitotic effect of the synthetic garlic oil on cancer cells which eventually led to cell death was more pronounced and stable than that of the natural garlic oil. The main anti-neoplastic component is therefore, preliminary diallyl thiosulfonate (allitridi). [19] This garlic ingredient has also immune enhancing, [20] and blood lipid reducing effects, etc. [21,22]

3.        Pharmacokinetics

After intake of S35-labeled allitridi orally, the total radioactivity in organs peaked in four hours, and in eight hours it was reduced to half of the peak value. After intravenous injection of allitridi into mice, concentrations detected 10 minutes later were highest in the lungs, and in descending order in the heart, intestines, blood, fat, brain, muscles, spleen, and liver. The metabolism of allitridi in the body was very rapid; most of the intravenous dose was transformed into water-soluble metabolites within 10 minutes, and was rapidly distributed to all organs. The main route of excretion was the urine, and partly the feces. [19,23,24]

4.        Toxicity

Alltridi shows very low toxicity. LD50 of 134.9mg/kg in mice; 67.45 to 134.9 times higher than the therapeutic dose (1 to 2 mg/kg). [19] Rabbits fed with 0.15% of allitridi at a dose of 3ml/kg twice daily for 10 weeks show no pathological change in the liver, spleen, adrenal glands, and lungs. [25] 

               

D.   Clinical Applications: It has been used for: [4,26,27,28]

1.        Lyme Disease, as an anti-spirochete agent. Due to allitridi's small molecular weight (162.27), it is able to pass through the blood brain barrier.

2.     Bacterial infections. It suppresses gram positive and negative bacteria. Good for bronchitis, sinusitis. For tuberculosis, especially for drug-resistant T.B.

3.        Fungal infections, Candidiasis and deep fungal infections

4.        Protozoa infections, Amebic dysentery,

5.        Use as strong anti-oxidant

Allitirdi has been clinically used in China for more than twenty years. It is potent enough to eliminate most common infections such as bacillary dysentery, amebic dysentery, deep fungal infections (cryptococcus maligitis), whooping cough, endobronchial tuberculosis, toxoplasmosis, oxyuriasis, trichomonas vaginitis, etc. Recent studies done by the AIDS Research Alliance in Los Angeles also found that it can be used to treat cryptosporidiosis. [29]

 

D.    Packaging: Every bottle contain 30 capsules, every capsule contains 20mg of allitridi.

E.    Dose: For prevention, one capsule per day. To use for infections, two to three capsules three times a day.

 

References:

1.        The Great Dictionary of Chinese Materia Medica, Shanghai Science and Technology Press, 1988, p.110-115

2.        Ji YB, Pharmacological Action and Application of Available Composition of Traditional Chinese medicine, Helongjian Science and Technology Press, 1995, p.9

3.        Yin Jian et al., The Modern Studies and Clinical Applications of Chinese Materia Medica, Volume 1, Xue Huan Press, 1994, p.86

4.        Zhu Yan, Pharmacology and Applications of Chinese Materia Medica, People’s Health Press, 1958, p.1

5.        The Great Dictionary of Chinese Materia Medica, Shanghai Science and Technology Press, 1988, p.110-115

6.        Ji YB, Pharmacological Action and Application of Available Composition of Traditional Chinese medicine, Helongjian Science and Technology Press, 1995, p.9

7.        Yin Jian et al., The Modern Studies and Clinical Applications of Chinese Materia Medica, Volume 1, Xue Huan Press, 1994, p.86

8.        Zhu Yan, Pharmacology and Applications of Chinese Materia Medica, People’s Health Press, 1958, p.1

9.        Wang Jiaying et al., Chinese Journal of Internal Medicine, (6): 549, 1959

10.     Tang Pai, Chinese Journal of Medicine, 40(9): 721, 1954

11.     The Chinese Medicine Research Group of Zhuong Qing Medical College, Journal of Microbiology (China), 8(1): 52, 1960

12.     Dold H et al., C A, 47:9419, 1953

13.     Yang SS, The Proceedings of First National Conference of Chinese Society of Physiology, 1956, p.26

14.     Zao Renli et al., Chinese Journal of Dermatology, (4): 286, 1957

15.     Zhang DJ et al., Chinese Journal of Medicine, 4(2): 126, 1957

16.     Szynbna M et al., C A, 47, 2412, 1953

17.     Yi HB et al., Acta Academica Medicina Primai Shanghai 1956(1): 42

18.     Chen XY, Chinese Journal of Abstracts and Gynecology 1956(4): 395

19.     Kimura Y et al., C A 1966 63:1089d

20.     Kroening K et al., C A 1964 61:15206c

21.     Tumor Prevention and Treatment Group, 184 Hospital of Chinese PLA, Proceedings of the National Conference on Cooperative Research on Anti-Cancer Drugs, 1978, p.15

22.     Pharmacology Department, Hunan Medical College, Proceedings of the National Conference on Cooperative Research on Anti-Cancer Drugs, 1978, p.1

23.     Cytology Research Group of Tumor Research Unit of Hunan Medical College, Special Edition of National Conference on Cooperative Research on Anti-Cancer Drugs, 1977

24.     TCM Department, First Teaching Hospital of Hunan Medical College, Chinese Traditional and Herbal Drugs Communication 1976 (12): 29

25.     Qian BC, Academy of TCM, The References of TCM Review, 1979 (1): 40

26.     Bordia A et al., Arteriosclerosis, 1975 21(1): 15

27.     Fortunatov MN, Farmakologiia I Toksilologia (Russian) 1955 18(4): 43

28.     Shanghai No.2 Pharmaceutical Factory, Abstracts of Research Information on 35S-Allicin as Tracer in Mice. April 1979

29.     Shanghai No.2 Pharmaceutical Factory, Chinese Traditional and Herbal Drugs Communication 1976 (10): 8

30.     Ren CO et al., Northeastern Region Medical Journal 1952 (7): 617

31.     Third People’s Hospital, Shanghai Second Medical College, Chinese Traditional and Herbal Drugs Communication 1973 (2): 53

32.     TCM Department, First Teaching Hospital of Shanghai Second Medical College, Medical Research Communication 1977 (6): 39

33.     Fareed, G et al., First Study of high-dose Garlic Preparation Shows Promise for the Treatment of Cryptosporidum parvum Diarrhea. Searchlight, Spring, 1996, p.16