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About Dr. Zhang
Herbs

ZHANG CLINIC featured again in
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Formula List
AI # 3 Capsule
Allicin Capsule
Artemisia Capsule
Artemisia 2 Capsule
(Double Potency)
BM Capsule
Capillaris Combination
Circulation P Capsule
Copmine Formula
Coptis Capsule
Cordyceps Capsule
DH-Artemisinin Capsule
Gall Formula 1
Gineseng and Atractylodes Formula
Glycyrrhizin Capsule
GL2
Hepa Formula 1A
Hepa Formula 2
HerbLipido
HerbSom Capsule
HerbZac Capsule
HH Tablets
HH 2 Capsule
(Double Potency)
Ligustrin Capsule
Milk Thistle Plus
MVM Formula
Olivessence Capsule
Puerarin Capsule
R-5081 Capsule
R-OBG Capsule
Schisandra Plus
Sedin
TGP formula
Yunan Paiyao Capsule
 
Circulation P Capsule
Recommended Daily Dose:
Take one capsules, three times a day
 

(Individual Dosage May Vary. Please Consult Health Care Professional)
 

 

Herb Composition:

Hong Hua (Carthami flos), Tao Ren (Persicae semen), Dang Gui (Angelicae radix), Chuan Xiong (Ligusticum chuanziong),Di Huang( Rehmanniae radix),Chi shao( Paeoniae rubra radix), Niu Xi (Achyranthis radix),Zhie Kao (Citri aurantii fructus),Cai Hu (Bupleuri radix),Gan Cao (Glycyrrhizae radix), and Ji Gen (Platycodi radix).
And active ingredients: tanshinenone extracted from Dan Shen (Salviae Miltiorrhziae Radix), ferulic acid form Dang Gui, tetramethlpyrazine from Chuan Xiong, and arasaponin from San Qi (Panax notoginseng).

Traditional Use:
Traditionally, the formula was used for releasing blood stasis, typically for symptoms of dark or purplish tongue, cold hands and feet, dark rings around the eyes, liver palms, spider moles, dry and itchy skin, rashes, and upper abdominal discomfort. It has Qi and blood activation, stasis expelling, and pain releasing effects. (Bai G et al. 1995)

Pharmacology

1. Improvement of blood circulation/microcirculation:


This formula can noticeably ameliorate acute microcirculation disorders induced by macromolecule dextran in rats. It dilates microcapillaries, reduces the viscosity of blood, accelerates blood flow, and opens more microcapillary networks. The result is to increase blood infusion to the tissues to improve cellular level nutrition and oxidation and stop pathogenesis caused by the microcirculation disorder. (Fang QL, 1988) It has also shown the ability to accelerate the removal of the metabolic wastes from tissues. Additionally, it can clear coagulating factors in diffuse intravenous coagulation (DIC) and stop the progression of DIC. It can suppress the clustering of platelets, prevent micro-clot formation, and reduce the viscosity of the blood. At the same time, it did not prolong prothrombin time. This formula can restore the phagocytosis function of macrophages blocked by thorium dioxide in the liver and activate functions of reticular-endothelial system of the liver. Therefore, it can accelerate the clearance of the substances that promote blood coagulation in the DIC to hold or reverse the DIC development. (Tienjin First Center Hospital, 1977)

2. Hematological effects:

This formula does not prolong the calcium recovery time and does not prolong prothrombin time (PT) and partial thromboplastin time (PTT) of the blood. It has been shown to suppress platelet clustering triggered by adenosine diphosphate (ADP) (Tienjin First Center Hospital, 1977). Meng QD et al., found that taking this formula orally could suppress the clustering of platelets and release angina pectoris (Meng QD et al. 1986). Zhao et al. studied 17 patients suffering from pain caused by blood stasis. Their blood specific viscosity, serum viscosity, haematocrit (HCT) were higher than the normal range. After treatment using this formula, HCT showed obvious improvement. Wu QF, observed 97 cases of blood stasis patients, and found that after 20 days of treatment with this formula, all of them showed improvement in following measurements: whole blood and serum specific viscosity, red cell sedimentation rate, HCT, fibrin, and thrombosis formation. Studies using of individual herbs contained in this formula found that as a single herb, Dang Gui (Angelicae Radix), Chuan Xiong (Ligusticum chuanziong) Carthami flos, Persicae semen, Paeoniae rubra radix, all demonstrated effects in suppressing the clustering of platelets, slowing down blood coagulation, and improving the blood rheology (Wu QF 1986).
 

3. Immune regulatory effects:

It has been shown to enhance the phagocytosis capabilities of the macrophages to aid in the removal of circulatory immune complex (CIC) and regulate cellular and humeral immunity. In animal studies, this formula showed obvious ability to promote phagocytosis of macrophages in two strings of mice models. It also showed antagonistic effects to the suppressive effects of prednisone on phagocytes and restored phagocytosis functions induced by suppressive effects of prednisone. It can increase the number of antibody-producing lymph cell and keep them actively producing antibodies for a longer period of time. It also activated T and B lymph cells and regulated immune responses (Zhang LR,1987). Another study found this formula to promote phagocytosis of macrophages of mice and enhance their clearance of chicken red cells injected into the abdominal cavity of mice. This effect was shown to last for more than 20 hours (Zhang YF, 1985)

4. Effects on fat metabolisms:

In a rat model, this formula was given orally and showed that it could lower serum cholesterol level. (Fong YJ,1988) In another rat model, rats were continuously fed with a high fat diet and then given this formula. Results showed that it was able to lower the total cholesterol (TC) and triglyceride (TG) in the serum and liver. It was also shown to dramatically lower the level of low-density lipoprotein (LDL). To treat high lipidemia, this formula can be used to help eliminate lipid from the liver and blood, and lower TC and TG and raise high-density lipoprotein (HDL). (She DY, 1988)

5. Other effects:
Anti-inflammatory effects: this formula was shown to be able to noticeably suppress inflammatory granuloma formation. In a rat model, this formula was given orally and showed the ability to suppress granulome formation caused by an implant of a plastic ring on the skin. The rats treated with this formula showed higher adrenarine and thymus indexes (Fong YJ,1988, Zhang LR, 1987) In a respiratory distress syndrome (RDS) rabbit model, this formula was given orally and showed the ability to raise PaO2 and improve microcirculation and air exchange in the lungs. In a multiple organ failure rabbit model, this formula was given orally and showed the ability to recover the functioning of ATPase and mitochrondirial. (Cuai ZY, 1988)

Clinical Applications:

Fundamental TCM theory states that blood stasis is almost always present in long-term chronic diseases and illnesses. Thus, activating blood circulation and removing the blood stasis is a major treatment in chronic disorders and pain syndromes. The main applications of this formula are listed as the following:

1. Infectious diseases:
It has been used for chronic infectious diseases, such as tubucurosis (Li XH, 19830), osteomyelitis due to Bacillus brucellae (Lui YC, 1986), Used in inflammatory diseases to promote healing of inflamed tissue, such as chronic gastritis, costal chondritis, and dermatitis. (Wu JL, 1978, Zhang BQ 1988, Zhang SJ, 1980, Tang XY, 1985)

2. Chronic hepatitis and cirrhosis:
Used in conjunction with other liver-protective herbs, this formula can help promote the normalization of liver functions, reduce liver and spleen enlargement, promote water absorption in ascites, improve overall blood circulation and slow the progression of fibrosis. (Shi ZS, 1978) [9] The Tianjing Institute of Emergent Medicine in Tianjing, China, used this formula to treat 18 cases of ascites caused by cirrhosis and found its effectiveness to be 94%. It can also improve microcirculation in the liver. (Lu YH, 1987, Yang JY, 1987)

3. Cardiovascular disorders:
It has been used for treating heart failure with a 93.7% efficacy rate (Wang YL, 1986); arrhythmia with a 75% efficacy rate (Zheng Y, 1975); in treating coronary heart diseases this formula, EKG readings showed dramatic improvement as well as clinical symptoms (Liu ZL, 1976, Sun HW, 1984, Chen KJ, 1984, Sha XH, 1984); releasing hypertension symptoms with a 92% efficacy rate (Teng SF, 1985); Treating hyperlipoidemia with a high efficacy rate in lowering TC, TG, and HDL. (She DY,1988). It has been used to treat peripheral vasculitis and was effective in treating thrombosis in the deep veins, multiple large arteritis, and arteriosclerosis obliterans (Wang JY, 1985).

4. Gastrointestinal disorders:
It has been used in treating chronic gastritis, especially atrophic gastritis (Zhang BQ, 1988); duodenal ulceration (Wang JY, 1986); persistent hiccup and neurological vomiting (Cui JC, 1985) with a moderate efficacy rate.


5. Tumors:
It has been used for supportive treatment in brain tumors (Hunan TCM College, 1973); pheochromocytoma (Wang EX, 1975); trigenminal neurinoma (Li YX, 1965); breast fibroma (Sun HW, 1980), It showed the ability to release symptoms and prolong survival in primary hepatocellular carcinoma patients (Zheng SH, 1981) Preventing micro-thrombosis formation can effectively prevent cancer cells from being protected by the clustered platelet and RBC and therefore preventing metastasis via the blood stream.

6. Chronic Pain:
It has been used for releasing pain in trigenminal neuralgia (Teng YL, 1985, Zhang JG, 1985). For neurological headaches (Liu QY, 1983), migraine and blood vessel related headaches (Yang JY, 1987, Han ZL, 1986), headaches caused by injuries (Ma ZL, 1988), pediatric headaches (Wang L, 1983), headaches caused by arteriosclerosis (Wang LF, 1965), and gynecological pains, such as painful menstruation (Tian ZL, 1984, Men CF, 1981, Lu F, 1987).
7. Chronic inflammation: It has been used for chronic laryngitis (Cai YF, 1979) retinitis, dermatitis (Tang XY, 1985), endometritis (Wnag HC, 1979), costal chondritis (Zhang SJ, 1980), and phlebitis (Wang JY, 1985). It’s mechanism in regulating chronic inflammation is by removing the immune complexes that trigger the inflammation. This results in accelerated healing.


References:
Bai G et al., Research and Applications of Chinese Herbal Formulas, Chinese Science and Technology Press, 1995, p.403 –411
Bien TJ, Chinese J of Dermatology, 1980, (1):57
Cai YF, Liaoyin Chinese Medicine, 1979, (6):26
Chen KJ, J Chinese Medicine, 1984, (11):9
Cuei ZY, Chinese Bulleten of Pharmacology, 1988, 3(5):25
Cui JC, J of Chinese Medicine, 1985, 26(12):47
Fang QL, Chinese Patent Medicine, 1988, (7):29
Fong YJ, J Shan Xi Chinese Medcine,1988, 9(3):126
Han ZL, Jilin Chinese Medicine,1986, (6):21
Li XH, Jiangxi Chinese medicine, 1983, (4):44
Li YX, Zhejiang Chinese Medicine, 1965, (3):34
Liu XQ, Shan Xi Chinese Medicne, 1983, (2):11
Liu YC, Hebei Chinese Medicine, 1986, (4):25
Liu ZL, Hunan Chinese Medicine, 1976, (2):4
Lu F, Hubei Chinese Medicine, 1987, (1)14
Lu YH, Shichuang Chinese Meidicne, 1987, 5(3):22
Ma ZL, Xinjiang Chinese Mediicne, 1988, (2):23
Meng CF, Henan Chinese Medicine, (3):39
Meng QD et al., The Second Conference on The Studies of Blood Activation and Stasis Expelling, 1986, P.150
Sha XH, J Chinese Medicine, 1984, (10):12
She DY, CJITWM, 1988, 8(10):601
Shi ZS, J of New Medicine, 1978, (9):36
Sun HW, J of Chinese Medicine, 1980, 21(2):177
Sun HW, Jilin Chinese Medicine,, 1984, (3):21
Tang XY, Helongjiang Chinese Medicine, 1985, (6):37
Teng SF, J Beijing Chinese Medicine, 1985, (6):34
Teng YL, Jilin Chinese Medicine, 1985, (5):19
Tian ZL, Zhejiang Chinese Medicine, 1984, (6):270
Tienjin First Center Hospital, Chinese J of Internal Medicine, 1977, 2(2):79
Wang EX, Shanxi New Medicine, 1975, (1):59
Wang HC, Symposium of Wang HC’s Clinical Experiences, Shanxi People’s Press, 1979
Wang JY, CJITWM, 1985 5(5):269
Wang JY, Hubei Chinese Medicine, 1986, (5):43
Wang L, Zhejiang Chinese Medicine, 1983,(9):425
Wang LF, J of Traditional Chinese Medicine,1965, (4):29
Wang YL, Hebei Chinese Medicine, 1986, (1):10
Wu JL, Academic J of Henan College of TCM, 1978, (2):28
Wu QF, The Second Conference on The Studies of Blood Activation and Stasis Expelling, 1986, P.155
Yang JY, J New Chinese medicine, 1987, 19(5):48
Zhang BQ, Helongjiang Chinese Mediicne, 1988, (2):4
Zhang JG, CJITWM, 1985,5(8):502
Zhang LR, Tienjin Medical J., 1987, 15 (9):544
Zhang RJ, J TCM, 1980, 21 (6):35
Zhang SJ, Traditional Chinese Medicine, 1980, 21(6):35
Zhang YF, The Pharmacology and Clinics of Chinese Meteria Medica, 1985, 1(1):14
Zheng SH, Liaoning Chinese Medicine, 1981, (9):15
Zheng Y, Medical Data, 1975, (3):26