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Herb Distribution @
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Tel:  (212) 573-9584 
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Herbs

ZHANG CLINIC featured again in
Dr. Weil's "Self Healing" newsletter

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Formula List
AI # 3 Capsule
Allicin Capsule
Artemisia Capsule
Artemisia 2 Capsule
(Double Potency)
BM Capsule
Capillaris Combination
Circulation P Capsule
Copmine Formula
Coptis Capsule
Cordyceps Capsule
DH-Artemisinin Capsule
Gall Formula 1
Gineseng and Atractylodes Formula
Glycyrrhizin Capsule
GL2
Hepa Formula 1A
Hepa Formula 2
HerbLipido
HerbSom Capsule
HerbZac Capsule
HH Tablets
HH 2 Capsule
(Double Potency)
Ligustrin Capsule
Milk Thistle Plus
MVM Formula
Olivessence Capsule
Puerarin Capsule
R-5081 Capsule
R-OBG Capsule
Schisandra Plus
Sedin
TGP formula
Yunan Paiyao Capsule
 
R-OBG Capsule
Recommended Daily Dose:
3 Capsules, 3 Times a Day

(Individual Dosage May Vary. Please Your Consult Health Care Professional)

(A herbal product formulated by Zhang’s Clinic and manufactured and distributed by HepaPro Corporation)
Neo-plastic disorders of female reproductive system can be categorized into relatively benign growths, such as: endometrioses, uterine fibroids, fibrocystic lumps in the breast, and ovarian cysts. More serious neo-plastic disorders include malignant growths, such as: ovarian cancer, cervical cancer, uterine cancer, and breast cancer. Many women are affected and most of these conditions are related to imbalances of female hormones, such as estrogen and their receptors. In China, much research has gone into the development of effective treatments for the regulation of female hormones and related disorders. Using traditional Chinese medicine as a foundation, modern scientific research has isolated many herbal substances that can effectively treat and regulate hormone imbalances and related disorders. Theoretical studies on these mechanisms found that among other effects, three commonly used herbs in the formula R-OBG Capsule can help block estrogen receptors (ER) and regulate hormone imbalances.

1. The herbal composition:
Zi Cao (Lithospermum erythrozhizon), Bai Hua She She Cao (Oldenlandiae Herba), Ban Zhi Lian (Scutellariae Barbatae), San Leng (Sparganii Rhizoma), E Zhu (Zedoariae Rhizoma), Huang Qin (Scutellariae Radix), Yi Yi Ren (Coicis Semen),Huang Qi (Astragali Radix). Dang Shen (Codonopsis Pilosulae Radix),Dan Shen (Salviae Miltiorrhziae Radix), Tu Fu Ling (Smilacis Glabrae Rhizoma), and Yu Jin (Curcuma aromatica).

2. Traditional use in Chinese medicine:

Traditionally these herbs have been used for anti-infection purposes and cancerous diseases. According to TCM theory, the three main herbs, Zi Cao, Bai Hua She She Cao, and Ban Zhi Lian have properties described as “heat clearing and toxin resolving” and “blood activating and stasis expelling” and have been used for general conditions such as furuncles, bruising and swelling, external traumas and wounds, and jaundice.
 

3. Pharmacology of main herbal ingredients:


3.1. Effects in blockage of estrogen receptors:

Studies showed that three main herbs in this formula, Scutellariae Barbatae (Ban Zhi Lian), Lithospermum erythrozhizon (Zi Cao), and Oldenlandiae Herba (Bai Hua She She Cao) demonstrated anti-inflammatory and anti-cancer effects in animal models. These studies were conducted at The University of Texas MD Anderson Cancer Center. The initial findings showed that the herbs were able to provide an effective new therapy for estrogen-related cancers. They may also be useful in treating meningioma, endometriosis, breast, ovarian, and uterine cancer. (AAPS, 1995) They have shown a great affinity to estrogen receptors and actively bind to it. Therefore, by competing with estrogen in the body and blocking the estrogen from binding to ERs, they are able to inhibit estrogen uptake. The studies also demonstrated that these herbs were able to affect breast cancer and other estrogen related diseases, such as uterine cancer, meningioma, ovarian cancer, cervical cancer, and endometriosis. In addition, studies also found these substances to be safe with no acute or chronic toxicity. Ideally, these herbal substances can play a role in therapies that require conventional ER-blocking medications such as tamoxifen and help mitigate the side effects of long-term use.

3.2. Anti-cancer effects:

The three main herbs, Barbatae (Ban Zhi Lian), Lithospermum erythrozhizon (Zi Cao), and Oldenlandiae Herba (Bai Hua She She Cao) have been studied for their anti-cancer effects and results showed that all three herbs exhibited anti-cancer actions.

Ban Zhi Lian (Scutellariae Barbatae) can suppress acute granular leukemia cells. Studies with a cell-breathing method found that its suppressive rate was greater than 75% (Zeng SD, 1993) The polysaccharide SPS4 extracted from the herb showed certain suppressive effects on the sarcoma cell and ascetic hepatoma cells. (Mong YF et al., 1993). In addition, it showed strong anti-mutagenic effects. Its water extracts can suppress mutations caused by aflatoxin B1 (AF B1) and suppress AF B1 from combining with DNA. (Wong BY et al. 1992, 1992, 1993)
 

Bai Hua She She Cao (Oldenlandiae Herba) extracts, when used in higher concentration, showed suppressive effects on ascites cancer, Yoshida sarcoma, and leukemia cells in vitro. It was ineffective in treating Yoshida sarcoma in rats, U-14 uterine cancer, and sarcoma S-180 and L-1 ascitic lymphoma in vivo. Its anti-cancer effects may be a non-specific effect that only appears in higher concentrations. Other tests showed that it has suppressive effects on ascetic hepatoma cell effects and also suppressed mice implanted with S-180 sarcoma. The suppressive rate in mice was 57.4% and it was found that the mitosis activities were obviously suppressed and the cancer showed necrosis. (Pan QC et al. 1962)
 

Studies showed that Zi Cao (Lithospermum erythrozhizon)’s active ingredient shikonin, used at the dose of 10 mg/kg, can completely suppress the growth of ascites sarcoma 180 cells and prolong survival time by 92.5% in sarcoma implanted mice. Shikonan is a derivative of shidonin and has suppressive effects on sarcoma 180 and also carcinoma W256 cells. (Sankawa U et al. 1977) It showed suppressive effects on the growth cycle of Hela cells and also reduces the spontaneous incidence rate of breast cancer in mice. (New Medicine College of Jiangsu, 1977) Its anti-cancer action comes by its ability to enhance the activities of natural killer cells (NK). (Liu LH et al., 1990) When used as an adjunctive treatment during conventional radiotherapy in cancer patients, it showed sensitizing effects on the hepatocellular carcinoma and Lewis lung cancer cells and prolonged the survival time of cancer implanted mice after radiation therapy. (Hu YP et al. 1991) When used together with hyper-thermal treatment of cancer, it showed synergistic effects. (Eca-109 cancer cells treated with 43° C hyper thermal treatment alone showed the suppressive effect of stopping mitosis cycle was reversible; when the herbal extract was added, the suppression of the mitosis cycle became irreversible. (Wnag L, 1984)
 

4. Clinical Application in China:

Clinically, this formula have been used for various types of estrogen and estrogen receptor related conditions. It is especially useful for patients who need an alternative for long-term tamoxifen treatment to avoid harmful side-effects.

5. Dosage and packaging:
Each capsule contains 500 mg of the extracts.
Each bottle contains 90 capsules.
Take three capsules, three times a day.
 

6. References:
AAPS (American Association of Pharmaceutical Scientists) News Release, New study reveals common herbs offer effective treatment for cancers affecting women, Miami, Nov 7, 1995,
Hu YP et al., 1991, J of Cancer Treatment and Prevention Research, 18(2):71
Liu LH et al., 1990, Chinese J of Immunology, 6(3):154
Mong YF et al., J of Biochemistry, 1993, 9(2):224
New Medicine College of Jiangsu, 1977, The Great Dictionary of Chinese Meterial Medica, Shanghai People’s Publishing House, p. 2342
Pan QC, et al., 1962, The Symposium of Chinese Pharmacology Society of 1962, Chinese Pharmacology Society,
Sankawa U et al., 1977, Chem Phar Bull, 25(9):2392
Wang L, 1984, Jinlin Medicine, 5(4):30
Wong BY et al., 1992, Mutal Res, 279(3):209
Wong BY et al., 1992, Cancer lett, 62(2):123
Wong BY et al., 1993, Cancer Lett, 68(1):75
Zeng SD, Encyclopedia of Chinese Materia Medica, Harbin Publication House, 1993, p.262