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About Dr. Zhang
Herbs

ZHANG CLINIC featured again in
Dr. Weil's "Self Healing" newsletter

Click here to read the excerpt

Formula List
AI # 3 Capsule
Allicin Capsule
Artemisia Capsule
Artemisia 2 Capsule
(Double Potency)
BM Capsule
Capillaris Combination
Circulation P Capsule
Copmine Formula
Coptis Capsule
Cordyceps Capsule
DH-Artemisinin Capsule
Gall Formula 1
Gineseng and Atractylodes Formula
Glycyrrhizin Capsule
GL2
Hepa Formula 1A
Hepa Formula 2
HerbLipido
HerbSom Capsule
HerbZac Capsule
HH Tablets
HH 2 Capsule
(Double Potency)
Ligustrin Capsule
Milk Thistle Plus
MVM Formula
Olivessence Capsule
Puerarin Capsule
R-5081 Capsule
R-OBG Capsule
Schisandra Plus
Sedin
TGP formula
Yunan Paiyao Capsule
 

All herbal formulas listed are part of Zhang's Clinic comprehensive treatment process. we strongly encourage patient feedback and communication and are ready to answer any questions directly or via our public web forum

 

Copmine Tablet’s pharmacological features can be used to raise WBC, platelet counts,  lower  portal vein pressure, and is also anti-fibrotic.

  Copmine Tablet

1. Original Herb:

The root of Berberis poiretii Schined and Coptis chinesis Franch 

2. Description in Traditional Chinese Medicine [1]:

  The Chinese name of the Copmine tablet is Huang-lien.  Huang-lien is a commonly used herb that was first recorded as being used about 2,000 years ago in Shen Nun Ben Cao Jing as a high-grade herb. It has bitter flavor and cold properties. TCM considered it to have the following

actions: to dispel heat, dry dampness, purge fire, and remove toxin. It has been
used for fidgets due to extreme heat, sensations of fullness in the chest and
abdomen, thirst, diarrhea due to heat, abdominal pain, tenesmus, hemoptysis,
epistaxis, conjunctivitis, tumors, and oral ulceration.

3. Chemical Composition:

The main ingredient of this tablet is berbamine, an alkaloid [2].

4. Pharmacology:

Effects on White Blood Cells and Lymph Nodes:
Berbamine significantly increased WBC count.

In rats and dogs models with leukopenia induced by cyclophosphamide, intraperitoneal injection of berbamine produced a significant antagonistic effect.  This was evidenced by the mitigation of WBC reduction, the accelerated improvement of WBC counts following the discontinuation of cyclophosphamide, and the tendency of platelet counts to increase [3,4]. Similar incremental effects on WBC were obtained in normal rabbits and orcyclophosphamide-induced leukopenic mice given methylberbamine extracted from the herb [5]. It can also activate lymph nodes, increasing RNA content and concentration.   It has elicited the cellular reaction of the plasmoblasts and plasmocytes [6].

 

B. Hypotensive Action:

An intravenous injection of 1.5 mg/kg of berbamine hydrochloride caused
transient lowering of blood pressure and de-perspiration [7]. IV injection
at a dose of 5-10 mg/kg caused a marked reduction of blood pressure in
anesthetized cats, dogs, or rabbits. The effects were proportional to the
dosage [8]. Experiments have shown that berbamine increased blood flow in the
perfuse hind limbs of rats by 95.5%.  This suggests that direct vasodilation as the
hypotensive mechanism [9]. Further evidence indicated that the hypotensive
effect of berbamine was related to the release of histamine from the tissue,
since it could be antagonized by dimegtine meteate[8]. Like tetrandrine, the
hypotensive action of berbamine was increased after methylation [10].

 
C. Choleretic Action:

The whole herb can reduce the tension and contractability of the gall bladder and increase bile flow. It can also relieve pain and inflammation in the gall bladder [11,12].

Berbamine can stimulate bile secretion and has been shown to increase bilirubin excretion by fivefold within 5 hours [13].

D. Anti-Silicosis Action:

Berbamine was proven to have significant prophylactic and therapeutic effects
on experimental silicosis in rats. It slowed down the increase of collagens in
the lungs of the animal with dust inhalation, thus retarding the pathogenic
process. Treatment with berbamine arrested the further development of lung
lesions at the pre-treatment stage. These results suggest that the mechanisms of
berbamine on experimental silicosis lies in the inhibition of fibrosis activity.
 [14,15].


E. Anti-bacterial Effects:


Berbamine exhibited anti-bacterial activity; its MIC were as follows:
250 ug/ml for Stephylococcusaureus and Escherichia coli, 500 ug/ml for
purulent streptococci
, 33 ug/ml for Streptococcus viridans, and 1500 ug/ml for
Pseudomonasaeruginosa
and Salmonella typhi [16].

F. Toxicity:


The LD50 of berbamine hydrochloride in mice by intragastric administration was
1700 200 mg/kg; by intravenous injection, it was 17.4 mg/kg. In the treatment of
experimental silicosis in rats, 250 mg/kg of berbamine hydrochloride given by the
mouth three times a week for five months did not result in abnormalities [3,
4, 15]. Its therapeutic index is high and safe for clinical use.

5. Clinical study in China:

A. Leukopenia:


In 162 patients with leukopenia due to radiotherapy, chemotherapy, tumors,
benzene, methylbenzene, trinitrobenzene, uranium, X-ray, and drugs such as
aspirin and chlorampenicol, good therapeutic effects were achieved with
berbamine tablets (50 mg, three times a day). In 64 cases due to radiotherapy or
chemotherapy, marked effects were obtained in 11 cases, and moderate effects
in 32 cases [4].


B. Silicosis [14,15] and anti-fibrosis in liver diseases.

C. Hypertension

Berbamine’s effective rate in treating essential hypertension in 65 cases was 72.3%.

 
Reference
[1] The Great Dictionary of Chinese Materia Medica, Shanghai Science and
Technology Publish, 1986, p. 2022-2030
[2] Deng WL, Coptis, Pharmacology and Applications of Chinese Materia Medica,
1983, p.57
[3] Liu CX et al., Chinese Traditional and Herbal Drugs Communications 1979
(9):36
[4] Institute of Materia Medica, Chinese Academy of Medical Sciences, Medical
Research Communications 1978 (3):27
[5] Sun XH et al., Guiyang Zhongyi Xuebao (Journal of Guiyang College of
Traditional Chinese Medicine) 1980 (1):67
[6] Hasegawa C et al., Chemical Abstracts 1953 47:5011d
[7] Lahiri SC et al., Chemical Abstracts 1956 50:14128g
[8] Khan I et al., Life Sci 1969 8(19):993
[9] Zhou ZD et al., Acta Pharmaceutica Sinica 1980 15(4):248
[10] Naidovich LP et al., Chemical Abstracts 1976 86:114974
[11] Tsitsin NV et al., Atlas lekarstvennykh rastenil SSSR. Moscow; 1962. p.68
[12] Palamartsuk AS. Rasti Resursy 1974 10(2):237
[13] Vellluda CC et al., Chemical Abstracts 1959 53:15345a
[14] Industrial Health Department, Institute of Health ofthe Chinese Academy
of Medical Science, Medical Research Communications 1977(10):35
[15] Industrial Health Department, Institute of Health ofthe Chinese Academy
of Medical Science, Medical Research Communications 1977(10):38
[16] Lahiri SC et al., Ann Biochem and Exptl Med India 195818:49