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Herbs

ZHANG CLINIC featured again in
Dr. Weil's "Self Healing" newsletter

Click here to read the excerpt

Formula List
AI # 3 Capsule
Allicin Capsule
Artemisia Capsule
Artemisia 2 Capsule
(Double Potency)
BM Capsule
Capillaris Combination
Circulation P Capsule
Copmine Formula
Coptis Capsule
Cordyceps Capsule
DH-Artemisinin Capsule
Gall Formula 1
Gineseng and Atractylodes Formula
Glycyrrhizin Capsule
GL2
Hepa Formula 1A
Hepa Formula 2
HerbLipido
HerbSom Capsule
HerbZac Capsule
HH Tablets
HH 2 Capsule
(Double Potency)
Ligustrin Capsule
Milk Thistle Plus
MVM Formula
Olivessence Capsule
Puerarin Capsule
R-5081 Capsule
R-OBG Capsule
Schisandra Plus
Sedin
TGP formula
Yunan Paiyao Capsule
 

 

Gall Formula No. 1
Recommended Daily Dose:
2 Capsules, 3 Times a Day

(Individual Dosage May Vary. Please Your Consult Health Care Professional)

 

Herbal Composition:

Angelica Radix

Tang kuei

Artemisiae capillaris Herba

Yin chen

Bupleuri Radix

Chai hu

Citri immaturi Pericarpium

Qing pi

Citri Pericarpium

Chen pi

Desmodii Herba

Jin qian cao

Gardeniae Fructus

Zhi zi

Gentianae Radix

Long dan

Salviae miltiorrhizae Radix

Dan shen

Saussureae Radix

Mu xiang

Scutellariae Radix

Huang qin

Taraxaci Herba

Pu gong ying

Pharmacology:

·     Bupleuri Radix is well-known in TCM for its liver-protective and cholagogic (facilitating bile secretion) actions. It can protect the liver from toxic damage caused by alactosamine.  It also can protect the liver from injury due to CCl4 and the mold Penicillium otatum. In animal studies, it has been shown to increase bile secretion and the amount of bile salt contained in the bile. It is a choleretic (bile secretion stimulating) substance and can normalize the bile-secreting function of the liver and normalize the chemical composition of the bile (the proportion of bilirubin and cholesterol). Its anti-inflammatory effect can also be used for cholangitis (inflammation of the gallbladder).

·     Artemisiae capillaris Herba, the main TCM herb for jaundice, has the following pharmacological actions:

(1)  *  Capillaris promotes bile secretion and excretion. It stimulates cholagogic effects in both healthy animals and those with CCl4-induced liver damage.

* One of the holeretic and cholagogic constituents of artemisia is 6,7-dimethoxy-coumarin, infusion of which at 0.2 and 0.3 g/kg into the duodenum of anesthetized rats increased bile secretion 30 minutes later by a mean of 50% and 180%, respectively. In dogs with chronic gallbladder fistulae, administration of 6,7-dimethoxycourmarin at 0.3g/kg by mouth increased the production of bile by a mean of 74% in 3 hours. In rats, the use of this agent in combination with genipin obtained from the fruit of Gardeniae jasminoides produced a synergistic effect in promoting bile secretion. Its decoction can decrease the tone of the Oddi's sphincter in anesthetized dogs.

*  Two other cholertic and cholgogic principles, capillarisin and methylcapillarisin, have been isolated from Capillaris and have proved to be more potent than 6,7-dimethoxycoumarin.

(2)   Capillaris can protect the liver.
After daily injection of the decoction—0.61g to rats with CCl4-induced liver damage—histological examination on the 8th day revealed that compared to the control group, the testing group showed less swelling of liver cells, less fatty degeneration, and less necrosis. In addition, liver glycogen and RNA content were either fully normalized or close to full recovery, and ALT activity was markedly reduced. This is clear evidence demonstrating the liver-protective actions of this substance.

(3)    Capillaris' antilipemic (lowering blood lipids) and fibrolytic effects are applicable to chronic viral hepatitis treatment. Clinically, it has been used for hepatitis, biliary tract infections, and cholelithiasis (gallstones).

 

·     Desmodii styracifolium Herba is the main herb of Lithagogic Decoction for treating gallstones. It possesses cholagogic, choleretic (bile secretion facilitating), and lithogogic (gallstones expelling) effects. Intravenous infusion into the femoral vein, or intraduodenal administration of the decoction of this herb at 8g/kg in dogs markedly increased the bile collected. Drainage of the human duodenum showed that it exhibits choleretic actions. Bile excretion is likely promoted by the relaxation of the Oddi's sphincter following increase of intraductal pressure consequent to the increase of bile secreted by liver cells. Choleretic action facilitates excretion of sandy stones, abates biliary obstruction and pain, and reduction of jaundice.

·     In both acute and chronic experimental models, bile flow from the gallbladder was greatly increased in dogs given Lithagogic Decoction in which Desmodii is the chief ingredient. Furthermore, bile secretion was increased by 3 to 20 times, and concretion components in the bile were markedly decreased in 6 out of 7 anesthetized dogs. This occurred 10 to 20 minutes after administration of Lithagogic Decoction.

Simultaneously, the Oddi's sphincter relaxed, coinciding with peak choleretic effects. A 20 to 60% increase in bile secretion associated with the relaxation of the Oddi's sphincter in 4 cases of biliary fistulae was achieved after administration of this decoction. In vitro studies using fresh bile obtained from patients suffering from bile pigment stones showed that Lithagogic Decoction prevented the precipitation of stone-forming elements, indicating that this herb also has antilithiasis (stone-forming prevention) effects. The action of Lithagogic Decoction is believed to be related to the inhibition of beta-glucuronidase activity in the bile. The decoction appeared to minimize the formation of new stones in rabbits with transplanted cholesterol gallstones. It has been used clinically for gallbladder inflammation and stones.