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Formula List
AI # 3 Capsule
Allicin Capsule
Artemisia Capsule
Artemisia 2 Capsule
(Double Potency)
BM Capsule
Capillaris Combination
Circulation P Capsule
Copmine Formula
Coptis Capsule
Cordyceps Capsule
DH-Artemisinin Capsule
Gall Formula 1
Gineseng and Atractylodes Formula
Glycyrrhizin Capsule
GL2
Hepa Formula 1A
Hepa Formula 2
HerbLipido
HerbSom Capsule
HerbZac Capsule
HH Tablets
HH 2 Capsule
(Double Potency)
Ligustrin Capsule
Milk Thistle Plus
MVM Formula
Olivessence Capsule
Puerarin Capsule
R-5081 Capsule
R-OBG Capsule
Schisandra Plus
Sedin
TGP formula
Yunan Paiyao Capsule
 
GL-2 Capsule
Recommended Daily Dose:
1 Capsule, 2 Times a Day

(Individual Dosage May Vary. Please Your Consult Health Care Professional)


GL-2 Capsule is our alternative for the Glycyrrhizin [1] Capsule. It will have less effect on blood pressure and can be used for people with risk factors relating to hypertension. In addition, GL-2 will result in much less sodium retention and possible headaches. Since 1994, GL-2 has been used in China for treating chronic viral hepatitis [1, 2, 3, 4, 5, 6]. 

 

Original Herb:

Glycyrrhiza uralensis Fisch (licorice root)

Traditional Use in Traditional Chinese Medicine [7]:

        Licorice is the most frequently used herb in TCM and has been extensively studied.  TCM classifies licorice as a sweet and gentle herb and uses it to supplement the body, to clear “latent-heat”, to regulate the functions of the stomach, to expectorate the lung and to invigorate the “spleen”. It has also been used as an antipyretic, detoxicant, and anti-inflammatory agent.  In TCM formulas, it is used as a corrective adjutant and harmonizing ingredient in many herbal formulas. Clinically, it is used for cough, palpitation, stomachache, peptic ulcer, inflammation, and skin rashes.

Chemical Composition:

The GL-2 Capsule contains diamine salt of glycyrrhizic acid (GL), and Glycyrrhizin is potassium salt of GL.

Clinical Pharmacology:

        Since the main active ingredient of GL-2 and Glycyrrhizin is GL, these two substances have very similar pharmacological effects. 

1.        Liver protective effects and Clinical Applications: GL-2 can protect liver damage due to inflammation and restore the liver structure and functions from damage caused by carbon tetrachloride, thioacetamide, D-galactose.  The effects include lowering the ALT (SGPT) and reducing degeneration and necrosis. Clinically, GL-2 150 mg per day, for 60 days, 22/40 cases’ ALT normalized and six months follow up after the treatment found the rebound rate (13.3%) and was less than glycyrrhizin (38.5%) [1]. Wang et al., treated 507 cases chronic HBV patient with GL-2 for 60 days and compare control group of 300 with glycyrrhizin and found that ALT, GGT, A/G, SB(serum bilirubin) normalization rate were higher than glycyrrhizin (p<0.05~0.01). Its effects on converting HBsAg and HBeAg were same as glycyrrhizin and HBV-DNA negative converting rate was significantly higher (p<0.05). Physical signs, such as jaundice, liver and spleen enlargement, improvement after 60 days of GL-2 treatment was statistically significant (p<0.05~0.01). Clinical symptoms improvement were very significant (p<0.05~0.001) [2,5]. Zhu et al., treated 56 cases of intractable chronic hepatitis patients who failed to respond to available treatments with larger doses of GL-2 for 8 weeks. They found that during 1,2,4,6,8 weeks, the ALT normalization rate were 4/56 (7.1%), 16/56 (28.6%), 32/56 (57.1%), 40/56 (71.4%), and 49/56 (87.5%) respectively. With the ALT improvement, symptoms were also improved [3].  Wu et al., found 80% histological improvement rate after three months intravenous infusion of 150mg GL-2 daily in biopsy findings of chronic hepatitis B patients [10]. Zhang et al., performed before and after treatment biopsy tests in 38 cases of chronic HBV patients and found that after GL-2 treatment inflammation grade reduced from 2.45±1.02 to 1.50±1.20 and found 50% of cases have an obvious histological improvement [4]. Fulminant hepatitis is a serious condition with high mortality and is difficult to treat. Wu SP et al use Gan Li Xin (GL-2) and liver cell growth promoting factor (PHGF) treated 44 cases during 1994 to 1996 and found the treatment can greatly reduce the death rate and found that it can reduce serum TNF-a and raise Il-2 [6]. Experimental hepatitis and cirrhosis studies on rats found that it can promote the regeneration of liver cells and at the same time inhibit fibrosis.  It can also reduce the g-globulin and the interstitial inflammation in the liver [9].

2.        Anti-viral effects: Clinical studies found that, intravenous infusion 400 to 1600 mg of GL can induce the generation of Il-2 and g-interferon in test animals and in humans [7].  It has anti-HIV effects and can suppress the replication of HIV [11] and suppress the cyto-toxic effects of HIV, but not suppress the revers-transcriptose activity [12]. It also suppresses the HIV infected cell to form fusion cells [11]. It also has obvious suppressive effects on VSV, AdV III, VV, and HSV-I viruses and can reduce the cytopathic changes [13]

3.        Other pharmacological effects: Anti-allergic, anti-inflammatory, and detoxifying activities are all important for its use in treating viral hepatitis.  Its anti-allergic and anti-inflammatory activities resemble the activities of glucocorticoid since GL maintains the level of active corticoid in the blood and increases endogenous corticoid by inhibiting the deactivation of glucocorticoid in the liver. Further, GL promotes the regeneration of inflammatory tissue in contrast with glucocorticoid which inhibits the regeneration. GL also inhibits the release of histamine from mast cell [14].

        4. Adverse Reactions: Clinical observation found that GL-2 has no bad effects on

          cardiovascular, hemotopoietic (blood cell generation), and kidney functions. It

          does not affect potassium, sodium and electrolytic balance. Only few people

          experience mild thirsty, dizziness and stomach bloating [1,2].

Reference:

        [1] Qiao GY, Gan Li Xin (GL-2), The Alternative for Glycyrrhizin, Liaonin Medical Journal, 1994, 8(4):219

[2] Wang BL et al., Clinical Observation of Gan Li Xin (GL-2) in Treating Chronic Hepatitis B, Chinese J. of Integrated Traditional and Western Liver Disease, 1995, 5(4):16-18

[3] Zhu YJ et al., Treating 56 Intractable Chronic Hepatitis Cases with Large Dose Gan Li Xin Intravenious Infusion, Chinese J. of Integrated Traditional and Western Liver Disease, 1997, 7(3):166-167

[4] Zhang LC et al., Histological Effects of Gan Li Xin on Chronic Hepatitis B, Chinese J. of Integrated Traditional and Western Liver Disease, 1998, 8(1):54

[5] Zhou GZ, et al., The Therapeutic Effects of Diamine Salt of Glycyrrhizic Acid on Chronic Hepatitis B, Chinese J of New Drugs and Clinical Remedies, 1999, 18(4):247-248

[6] Wu SP et al., Serum TNF-a and Il-2R Levels Before and After Gan Li Xin and PHGF Treatment in Fulminant Hepatitis Patients. Chin J Hepatol, June 1997, Vol.5 No.2,p.68

[7] Ying Jian et al., Modern Studies and Clinical Applications of Chinese Material Medica, 1994, p. 196

        [8]  Lian ZP, et al., Journal of Chinese Medical University, 1991; 9(4):257

      [9] Han JH et al.,

      [10] Wu SM et al., Gan Li Xin, A New Anti-Hepatitis Remedy, Modern Application

       Pharmacy, 1995, 12(4):52

      [11] Hattori T. et al., Preliminary evidence for inhibitory effect of glycyrrhizin on

      HIV replication in patients with AIDS, Antiviral Research, 1989,(11):255

      [12] Ito M et al., Inhibitory effect of glycyrrhizin on the in vitro infectivity and

      Cytopathic activity of the HIV, Antiviral Research, 1989, (11):127

      [13] Chang YP et al., Chinese J of Chinese Material Medica, 1989,14(4):44-46

      [14] Wang BJ, Modern Pharmacology of Chinese Material Medica, Tianjin Science

      and Technology Press, 1999, p.1183-1187