ZHANG CLINIC®
PROTOCOLS
Herb Distribution @
www.hepapro.com



Zhang Clinic
20 E. 46th Street
Suite 1402
New York,  NY 10017

Tel:  (212) 573-9584 
Fax: (212) 573-6045

 
This is a password-protected private information web. Materials presented here is only intended for viewing by Zhang Clinic employees, affiliated professional practitioners and clinic patients.
Hepatitis C
 
Lyme Disease
Hepatitis Peripheral Complications Colitis /Crohn's Disease (Inflammatory Bowel Syndrome)
Non-Alcoholic Steatohepatitis (NASH): Fatty Liver Liver Cirrhosis Related Conditions
Alcoholic Liver Disease  
Auto-Immune Hepatitis
Cholestatic Hepatitis
SinoMed Research Home
About Dr. Zhang
Herbs

ZHANG CLINIC featured again in
Dr. Weil's "Self Healing" newsletter

Click here to read the excerpt

Formula List
AI # 3 Capsule
Allicin Capsule
Artemisia Capsule
Artemisia 2 Capsule
(Double Potency)
BM Capsule
Capillaris Combination
Circulation P Capsule
Copmine Formula
Coptis Capsule
Cordyceps Capsule
DH-Artemisinin Capsule
Gall Formula 1
Gineseng and Atractylodes Formula
Glycyrrhizin Capsule
GL2
Hepa Formula 1A
Hepa Formula 2
HerbLipido
HerbSom Capsule
HerbZac Capsule
HH Tablets
HH 2 Capsule
(Double Potency)
Ligustrin Capsule
Milk Thistle Plus
MVM Formula
Olivessence Capsule
Puerarin Capsule
R-5081 Capsule
R-OBG Capsule
Schisandra Plus
Sedin
TGP formula
Yunan Paiyao Capsule
 
Hepa Formula No. 1A
Recommended Daily Dose:
2 Capsules, 3 Times a Day

(Individual Dosage May Vary. Please Your Consult Health Care Professional)

 A.    Herbal Composition:

Scutellariae baicalebsus Radix, Silybum marianum fructus, Schizandrae Fructus, Panax notoginseng Radix, and Gardenia jasminoides fructus.,

B.      Pharmacology of major ingredients:


Scutellariae baicalebsus Radix:

Baicalein and baicalin are the active ingredients of this herb. They have extensive pharmacological uses that are effective in treating chronic viral hepatitis. Their detoxicant effects can enhance the liver’s detoxification function. Their liver protective and cholagogic, choleretic and spasmolytic effects can help facilitate bile secretion and help repair the inflammatory damage present in the liver. This wide spectrum of anti-microbial effects cover many common bacteria and myco-bacteria. They can also suppress fungi, protozoa, and certain viruses. Their anti-allergic and anti-inflammatory effects are especially useful in treating viral hepatitis, in which immunopathy is a major pathology. Due to the viremia of viral hepatitis, patients often to have a feverish feeling. This herb’s antipyretic effect is also very useful for dealing with these symptoms. Its sedative effects can help with the anxiety and depression of hepatitis patients. It is a very safe herb and especially orally taking, the toxicity is very low.

Clinically, it has been used for  infectious hepatitis, acute biliary tract infections, chronic bronchitis, scarlet fever, epidemic cerebrospinal meningitis, bacillary dysentery, leptospirosis, and hypertension. When used alone for treating acute viral hepatitis, it can reduce 79.1% of the patients’ ALT level to normal levels within 2 weeks. For chronic hepatitis, the effective rate is approximately 70%. 


 

Silybum marianum fructus:

The common name of this herb is milk thistle and it is the most well known liver protective herb in Europe. Its active ingredient is silymarin and has liver protective, cholagogic and cholertic effects. Animal studies found that it can protect the liver from damage of CCL4 and blood iron chloride intoxication. It can protect the liver from cirrhotic damages caused by alcohol and thioacetamide, and has been used in treating various liver diseases. The mechanism of its action may be attributed to its ability to stabilize the cell membrane of the liver cells and detoxify  harmful substances and repair the cell membrane. It can also protect the drug metabolic enzyme of the liver. In addition its beneficial effect on the liver, it can also protect the cardiac muscle from viral infections and lower blood pressure. Its anti-oxidental effect has brain protection mechanism from ischemic damage. Safety wise, it has a very low toxicity and has been proven to be safe for clinical use.

Clinically, it has been used for chronic hepatitis.  In a 201 patient clinical study, it was found that its over all effective rate was 74.6%. It has also been used for treating cirrhosis, fatty liver, liver damage from alcohol, intoxicated liver damages, and gallstones.


Schizandrae Fructus:

Animal studies have proved that extracts from the kernel of the fruit of schizandra (AEKFS) has the following effects:

1.        Lowering the ALT elevation caused by carbon tetrachloride (CCl4) induced liver damage.

2.        Reducing fat deposits in the liver cells caused by CCl4 intake.

3.        Reducing the histological damage of the liver cells caused by CCl4.

4.        Promoting glycogen and serum protein synthesis in the liver.

5.        Promoting liver regeneration after partial removal of the liver.

6.        Increasing metabolic enzymes in the liver.

Clinical trials using tablets made from the whole AEKFS, conducted in three hospitals in China found that of the 107 chronic viral hepatitis cases tested, 73 patients had their ALT level normalized with the improvement of physical symptoms.  There were no serious side effects reported.

From the fruit of schizandra, seven active liver-enzyme-lowering ingredients have been isolated. Schizandra can improve the function of the membrane of the liver cell and reduce its leakage.  Its extracts, Schisandrin B and C can enhance the detoxification function of the liver, promoting protein and liver glycogen synthesis.  A precursor of synthesized Schisandrin C can effectively normalize liver functions.  The effective rate of Schisandrins in lowering liver enzymes is around 80%.  The enzyme level may rebound in about 60% of the patients after the treatment is stopped.  The rebound will happen within a half month to six months time.  Clinical observation found that Schizandra was more effective in lowering ALT than AST, and has no effects on turning HBsAg  negative.  Animal studies found that extract of schizandra can suppress the activity of ALT but there was no effect on AST, LDH.  At the Sixth National Hepatitis Conference of China (1990), it was reported that in the carbon tetrachloride toxic model of human liver embryo cell culture, extracts of schizandra can significantly reduce cell damage, and keep cell membranes intact.  The report effectively concluded that schizandra could protect the liver cell membrane.


 Panax notoginseng Radix:

The active ingredient of this herb is saponin, which has extensive therapeutic effects. It can effectively suppress ALT and AST elevation, increase SOD level in the liver and serum, reduce the MDA production and consumption of the glycogen, improve microcirculation of the liver, and reduce the damage of the mitocondria and endoplasmic reticulum. In the CCl4 intoxicated animal model, it reduced the liver damage caused by CCl4. It also has coronary dilation effects and can increase the coronary flow. It can improve myocardial oxygen consumption and anoxia tolerance, thus it has anti-acute myocardial ischemia effect. Its anti-inflammatory and analgesia effects can help to control the inflammation and dull pain in the liver. It is a very safe herb and its toxicity is very low.

 

Clinically, it has been used for hepatobiliary diseases to reduce ALT levels and increase the serum albumin. It is also used for coronary disease, hematuria, intraocular hemorrhage, and hyperlipidemial.

 


Gardenia jasminoides fructus:

The active ingredient of this herb is gardenoside. Its major pharmacological action is enhancing the liver functions. It can increase the activity of hepatic uridine diphosphate-glucose dehydrogenase (HUDGD). In animals with ligated common bile duct, the extract lowered the abnormally elevated AST and increased the activity of HUDGD. It can also prevent the elevation of ALT and AST caused by CCl4 intoxication. It has cholagogic and choleretic actions and can increase bile secretion. It addition, it also enhances the metabolism of bilirubin.