Scutellariae baicalebsus Radix, Silybum marianum fructus, Schizandrae
Fructus, Panax notoginseng
Radix, and Gardenia jasminoides fructus.,
Pharmacology of major ingredients:
and baicalin are the active ingredients of this herb. They have extensive
pharmacological uses that are effective in treating chronic viral
hepatitis. Their detoxicant effects can enhance the liver’s
detoxification function. Their liver protective and cholagogic, choleretic
and spasmolytic effects can help facilitate bile secretion and help repair
the inflammatory damage present in the liver. This wide spectrum of
anti-microbial effects cover many common bacteria and myco-bacteria. They
can also suppress fungi, protozoa, and certain viruses. Their
anti-allergic and anti-inflammatory effects are especially useful in
treating viral hepatitis, in which immunopathy is a major pathology. Due
to the viremia of viral hepatitis, patients often to have a feverish
feeling. This herb’s antipyretic effect is also very useful for dealing
with these symptoms. Its sedative effects can help with the anxiety and
depression of hepatitis patients. It is a very safe herb and especially
orally taking, the toxicity is very low.
it has been used for infectious
hepatitis, acute biliary tract infections, chronic bronchitis, scarlet
fever, epidemic cerebrospinal meningitis, bacillary dysentery,
leptospirosis, and hypertension. When used alone for treating acute viral
hepatitis, it can reduce 79.1% of the patients’ ALT level to normal
levels within 2 weeks. For chronic hepatitis, the effective rate is
common name of this herb is milk thistle and it is the most well known
liver protective herb in Europe. Its active ingredient is silymarin and
has liver protective, cholagogic and cholertic effects. Animal studies
found that it can protect the liver from damage of CCL4 and
blood iron chloride intoxication. It can protect the liver from cirrhotic
damages caused by alcohol and thioacetamide, and has been used in treating
various liver diseases. The mechanism of its action may be attributed to
its ability to stabilize the cell membrane of the liver cells and detoxify
harmful substances and repair the cell membrane. It can also
protect the drug metabolic enzyme of the liver. In addition its beneficial
effect on the liver, it can also protect the cardiac muscle from viral
infections and lower blood pressure. Its anti-oxidental effect has brain
protection mechanism from ischemic damage. Safety wise, it has a very low
toxicity and has been proven to be safe for clinical use.
it has been used for chronic hepatitis.
In a 201 patient clinical study, it was found that its over all
effective rate was 74.6%. It has also been used for treating cirrhosis,
fatty liver, liver damage from alcohol, intoxicated liver damages, and
Animal studies have proved that
extracts from the kernel of the fruit of schizandra (AEKFS) has the
Lowering the ALT elevation caused by carbon tetrachloride (CCl4)
induced liver damage.
Reducing fat deposits in the liver cells caused by CCl4
Reducing the histological damage of the liver cells caused by CCl4.
Promoting glycogen and serum protein synthesis in the liver.
Promoting liver regeneration after partial removal of the liver.
Increasing metabolic enzymes in the liver.
Clinical trials using tablets
made from the whole AEKFS, conducted in three hospitals in China found
that of the 107 chronic viral hepatitis cases tested, 73 patients had
their ALT level normalized with the improvement of physical symptoms.
There were no serious side effects reported.
From the fruit of schizandra,
seven active liver-enzyme-lowering ingredients have been isolated.
Schizandra can improve the function of the membrane of the liver cell and
reduce its leakage. Its
extracts, Schisandrin B and C can enhance the detoxification function of
the liver, promoting protein and liver glycogen synthesis.
A precursor of synthesized Schisandrin C can effectively normalize
liver functions. The
effective rate of Schisandrins in lowering liver enzymes is around 80%.
The enzyme level may rebound in about 60% of the patients after the
treatment is stopped. The
rebound will happen within a half month to six months time.
Clinical observation found that Schizandra was more effective in
lowering ALT than AST, and has no effects on turning HBsAg
studies found that extract of schizandra can suppress the activity of ALT
but there was no effect on AST, LDH. At the Sixth National Hepatitis Conference of China (1990),
it was reported that in the carbon tetrachloride toxic model of human
liver embryo cell culture, extracts of schizandra can significantly reduce
cell damage, and keep cell membranes intact.
The report effectively concluded that schizandra could protect the
liver cell membrane.
The active ingredient of this herb is saponin, which has
extensive therapeutic effects. It can effectively suppress ALT and AST
elevation, increase SOD level in the liver and serum, reduce the MDA
production and consumption of the glycogen, improve microcirculation of
the liver, and reduce the damage of the mitocondria and endoplasmic
reticulum. In the CCl4 intoxicated animal model, it reduced the
liver damage caused by CCl4. It also has coronary dilation
effects and can increase the coronary flow. It can improve myocardial
oxygen consumption and anoxia tolerance, thus it has anti-acute myocardial
ischemia effect. Its anti-inflammatory and analgesia effects can help to
control the inflammation and dull pain in the liver. It is a very safe
herb and its toxicity is very low.
Clinically, it has been used for hepatobiliary diseases
to reduce ALT levels and increase the serum albumin. It is also used for
coronary disease, hematuria, intraocular hemorrhage, and hyperlipidemial.
Gardenia jasminoides fructus:
The active ingredient of this herb is gardenoside. Its
major pharmacological action is enhancing the liver functions. It can
increase the activity of hepatic uridine diphosphate-glucose dehydrogenase
(HUDGD). In animals with ligated common bile duct, the extract lowered the
abnormally elevated AST and increased the activity of HUDGD. It can also
prevent the elevation of ALT and AST caused by CCl4
intoxication. It has cholagogic and choleretic actions and can increase
bile secretion. It addition, it also enhances the metabolism of bilirubin.