ZHANG CLINIC®
PROTOCOLS
Herb Distribution @
www.hepapro.com



Zhang Clinic
20 E. 46th Street
Suite 1402
New York,  NY 10017

Tel:  (212) 573-9584 
Fax: (212) 573-6045

 
This is a password-protected private information web. Materials presented here is only intended for viewing by Zhang Clinic employees, affiliated professional practitioners and clinic patients.
Hepatitis C
 
Lyme Disease
Hepatitis Peripheral Complications Colitis /Crohn's Disease (Inflammatory Bowel Syndrome)
Non-Alcoholic Steatohepatitis (NASH): Fatty Liver Liver Cirrhosis Related Conditions
Alcoholic Liver Disease  
Auto-Immune Hepatitis
Cholestatic Hepatitis
SinoMed Research Home
About Dr. Zhang
Herbs

ZHANG CLINIC featured again in
Dr. Weil's "Self Healing" newsletter

Click here to read the excerpt

Formula List
AI # 3 Capsule
Allicin Capsule
Artemisia Capsule
Artemisia 2 Capsule
(Double Potency)
BM Capsule
Capillaris Combination
Circulation P Capsule
Copmine Formula
Coptis Capsule
Cordyceps Capsule
DH-Artemisinin Capsule
Gall Formula 1
Gineseng and Atractylodes Formula
Glycyrrhizin Capsule
GL2
Hepa Formula 1A
Hepa Formula 2
HerbLipido
HerbSom Capsule
HerbZac Capsule
HH Tablets
HH 2 Capsule
(Double Potency)
Ligustrin Capsule
Milk Thistle Plus
MVM Formula
Olivessence Capsule
Puerarin Capsule
R-5081 Capsule
R-OBG Capsule
Schisandra Plus
Sedin
TGP formula
Yunan Paiyao Capsule
 
HH Capsule
Recommended Daily Dose:
One capsules, 3 Times a Day

(Individual Dosage May Vary. Please Your Consult Health Care Professional)


A. Original Herb:

Houttuyniae Herba is the leaf of Houttuynia cordata Thunb. (Saururaceae). [1]

B.  Chemical Composition:

The active ingredients of the herb are volatile oils consisting of decanoyl acetaldehyde, methyl-n-nonylketone, myrcene, lauric aldehyde, alpha-pinene, camphene, d-limonene, linalool, and caryophyllene.  The main anti-microbial ingredient is decanoyl acetaldehyde. [2]

C.   Pharmacology:

The chief antibacterial principle of H. cordata is decanoyl acetaldehyde. It is a labile compound that rapidly polymerizes upon purification. Its bond with sodium hydrogen sulfite is stable and exhibit antibacterial actions. [3,4]

HH exhibits strong anti-spirochete effects and has been effectively used to prevent and treat leptospirosis, an infectious disease caused by spirochetes. [5]

HH also exhibits significant inhibitory actions against various types of bacteria (including acid fast bacilli) and fungi. In vitro bacteriostatic tests showed that it markedly inhibited gram-positive and gram-negative bacteria. The most sensitive organisms were Staphylococcus aureus and its penicillin-resistant strains, Diplococcus pneumoniae, alpha Streptococcus, Hemophilus influenzae. Neisseria catarrhalis, and Salmonella typhi ranked second. Escherichia coli, Pseudomonas aeruginosa and Shigella dysenteriae showed marginal sensitivity. [5,6,7] Its MIC (minimum inhibitory concentration) against Staphylococcus aureus and its penicillin-resistant stains was determined to be 62.5-80 mcg/ml, Hemophilus influenzae 1.25mg/ml, and Mycobacterium tuberculosis H37 RV strain in Prodkauer-Beck medium 16mcg/ml. [8]

HH also inhibits Candida, albicans, Cryptococcus neoformans, Sporotruichum, Aspergillus, Chromomycosis fungus, Epidermophyton rubrum, Tinea imbricata, Microsporum gypseum, Microsporum ferrugineum, and sharkskin fungus at an MIC of 2mg/ml.  HH has inhibitory action against Diplococcus pneumoniae, Salmonella typhi, Staphylococcus aureus, Escherichia coli and Sporotrichum in vitro. It also exhibits strong inhibitory actions against Mycobacterium tuberculosis, both in vitro and in vivo with an MIC of 0.78-3.1 mcg/ml. Intraperitoneal injection of this agent to tuberculoses mice at 1mg/mouse prolonged the survival period of the animals by 62 days; the therapeutic effect was enhanced when the agent was mixed with the animal feed. [9,10]

Besides anti-infectious effects, HH has immune enhancing effects that promote phagocytic ability of peripheral leukocytes, increase the serum properidin level and enhance lysozyme activity. Its strengthening of body resistance is of great importance in the treatment of infectious diseases. It diuretic and anti-inflammatory effects are also important in treating infectious diseases. [11,12]

D.      Pharmacokinetic studies found that its half-life is 3.5 hours in rat gastrointestinal tract. It was quickly distributed, mostly in the lungs, next in the heart, liver and kidney, and minimally in the serum. [13]

E.       Toxicity: HH is very low in toxicity. LD50 in mice is 1.6± 0.81 g/kg. Intravenous infusion of 38 or 47 mg/kg to dogs did not cause any abnormalities or histological changes in the heart, lungs, liver, kidney, spleen, stomach and intestine. Sub-acute toxicity tests showed that daily oral intake of 80 or 160 mg/kg of the agent to dogs for 30 days did not influence appetite, blood analysis and liver functions. In some cases, it did cause vomiting and increased salivation. [14]

F.       Clinical Applications:

1)       Leptospirosis [15,16] and Lyme Disease

2)       Respiratory tract infections [17,18]

3)       Chronic cervicitis [19]

4)       Otorhinolaryngological infections [20]

G.       

Packaging:  
Each capsule contains 90mg of Decanoyl acetaldehyde and absorbing substance. One bottle contains 45 tablets.

Dose:
Take one capsule, three times a day.

 

References:

1.        The Great Dictionary of Chinese Materia Medica, Shanghai Science and Technology Press, 1988, p.1439-1441

2.        Liu YL et al., Pharmaceutical Abstracts. Chinese Pharmaceutical Association (Beijing Branch). Sept 1978. p.231

3.        Kosuge T. J of the Pharmaceutical Society of Japan (Tokyo) 1975, 72(10):1227

4.        Isogai Y. C. A. 1953, 47:2832a

5.        Leptospirosis Research Unit, Chengdu College if traditional Chinese Medicine. Scientific Research Compilation. 3rd edition,  Chengdu College of TCM, 1972. p.59

6.        Yang HC et al., C A. 1953 47:8175d

7.        Leptospirosis Research Unit, Sichuan Institute of Chinese Materia Medica. Research Information on  TCM, 1971 (6):34

8.        Jiangxi Medical Information (Jiangxi School of Pharmacy), 1972 (2):12

9.        Kosuge T et al.,, . J of the Pharmaceutical Society of Japan (Tokyo) 1953, 73(5{):435; 1956 76(4):386; 74(8):819;

10.      Materia Medica Section, Bateriology-Immunology Dept. Beijing Institute of Tuberculosis. Pharmaceutical Abstracts. Chinese Pharmaceutical Association, 1978, p.264

11.     Bronchitis Unit, Third People’s Hospital of Shanghai Second Medical College. J of TCM, 1973 (7):25

12.     Medical Laboratory, Teaching Hospital of Jiangxi College of TCM, New Medical Information, 1975 (2):46

13.     Materia Medica Unit, Jiangxi Second people’s Hospital. Chinese J of Medicine, 1976 56(7):454

14.     Jiangxi College of TCM, New Medical Information, 1977 (1):38

15.     Liang YQ, Heilongjiang Medical J 1978(5):22

16.     TCM Dept. Chengdu College of TCM, Acientific research Compilation. 4th edition, 1975, p.6

17.     Pediatrics Dept, Fujian People’s Hospital. Medical Information of Fuzhou Institute of  Medical Science, 1975 (2):62

18.     Zhong CY, People Military Medicine 1979 (3):39

19.     Qui CQ et al., New Chinese Medicine 1979 10(12):601

20.     Ji HK et al., J of TCM 1979 (5):28