Recommended Daily Dose:
One Capsule, 3 Times a Day
(Individual Dosage May Vary. Please Your Consult Health Care
Fructus (Ligustrum lucidum Ait)
Traditional Chinese Medicine uses ligustrum as a
tonic for the liver and kidneys, principally as a treatment of symptoms
associated with "yin deficiencies," such as dizziness, blurred
vision, tinnitus, premature graying of hair, and low-back ache.
Ligustrin is a highly purified extract of Ligustrum
lucidum Fructus. Its major chemical component is oleanolic acid. Other
components include acetyloleanolic acid, betulin, lupeol, salidroside,
mannitol, oleic acid, linolenic acid, and palmitic acid.
Ligustrin protects the liver from chemical and
biological injuries through the following actions.
· Ligustrin helpe lower the liver enzyme ALT (SGPT) level. In
experimental cirrhosis studies, ligustrin inhibited degeneration and
reduced necrosis of liver cells. It can increase glycogen in the liver,
accelerate repair of necrosed tissue, and promote regeneration of liver
cells. It can also inhibit inflammation and collagen formation.
· Ligustin raises the WBC count and is used to treat
leukopenia caused by radiation and chemotherapy.
· In clinical trials for treating acute or chronic hepatitis,
it can rapidly reduce ALT, AST, and jaundice; it has a 90% clinical cure
rate for acute icterohepatitis and a 70% effectiveness rate for chronic
· Ligustrin has immune-regulatory effects, specifically, it
promotes lymphoblast cell transformation, suppresses Ts cells, increases
Th cells, and promotes phagocytosis of macrophages.
· Ligustrin can increase coronary blood flow.
· Acute and chronic toxicity tests have shown that ligustrin
has very low toxicity. After injecting dogs with 50mg/kg IV and mice with
5mg/20g IV, 24 hours of observation found no adverse reactions. After
injecting rabbits with 50mg/kg IP daily for 6 to 12 weeks, no heart,
liver, or kidney disorders were found.