Introducing A Specially Designed Multiple Vitamin and
Mineral Supplement for People with Liver Disorders
Many patients with liver disorders ask me what are the
proper vitamins and mineral supplements they should take to help them
maintain good health. To meet their request, I have asked Dr. Stephen
Paul, Ph D. of biochemistry and an authority in dietary supplement
industry, to design a special formula that can be safely and effectively
used by people with liver disorders. He has completed his research and
formulated the MVM Liver Formula. The HepaPro Corporation has adopted this
product into their line of supplements. The following is an explanation
given by Dr. Paul on the ingredients of this formula and why they are
beneficial for people with liver disorders.
Dr. Qingcai Zhang
MVM Liver Formula
MVM Liver Formula is specially formulated to protect
and strengthen the liver, replenish nutrient deficiencies and boost
general immunity. It contains nutrients that have been shown to be safe
and effective when used as recommended, by people with hepatitis and other
While a good diet provides adequate supplies of
nutrients for most healthy people, patients with hepatitis and other liver
disorders often have vitamin and mineral deficiencies.
The B vitamins are all required for the normal
functioning of specific enzymes. They are responsible for many important
processes such as converting sugar into usable energy and keeping cells
healthy. Because these vitamins are vital to a vigorous long life, not
getting them can lead to serious problems. Especially for patients with
liver disorders, fatigue is the most common symptom and with the help of B
vitamins the energy generating mechanism in the liver will be functioning
well and can help to release this symptom.
B vitamins provide:
health of the skin, bones, hair and muscle
· health of the
mucosal membranes, particularly around the mouth
health and bowel function
· relief of
moodiness, restlessness, irritability, insomnia and fatigue
brain cell function and health
· relief from
skin problems, including dry and itchy skin and rashes
· relief from
B complex vitamins are often recommended for liver
problems. They support certain detoxification pathways in the liver.
Thiamin (Vitamin B1) is often deficient in patients
with liver disease. Thiamin aids
in the proper function of the mucous membranes, nervous system, muscles,
heart, and metabolism. It aids
energy levels, decreases pain, and may fight viruses (e.g., Herpes
Zoster). Symptoms of thiamin
deficiency include poor memory, fatigue, muscle weakness and blindness.
These symptoms are also common in liver disorders. Over time, thiamin
deficiency can lead to heart disease and brain damage.
Riboflavin (Vitamin B2) enables carbohydrates,
proteins, and fats to release energy. Riboflavin is needed for normal
reproduction, growth, and repair of skin, hair, nails, and joints. It is
also important to the immune system.
Niacinamide (Vitamin B3) is necessary for utilization
of fats, tissue respiration and production of polysaccharides. This
vitamin aids in release of energy from foods, helps synthesize DNA. It
is also involved in the manufacture of sex and adrenal hormones.
Pantothenic acid (Vitamin B5) is needed for certain
detoxification processes in the liver as well as conjugation of bile
acids produced by the liver. Bile acids must be conjugated in order to
help in the assimilation of dietary fats.
B6) has a wide variety of metabolic functions in the body, especially in
amino acid metabolism and in the central nervous system, where it
supports production of gamma-aminobutyric acid (GABA). Pyridoxine
deficiency causes blood, skin, and nerve changes. This vitamin is unique
in that both deficiency and excess can cause peripheral neuropathy.
Pyridoxine is needed for proper immune function. Deficiency of this
nutrient impairs immunity. Hepatitis and liver disorders increase the
risk of pyridoxine deficiency.
Vitamin B12 promotes healthy blood cells, appetite
and mental function. Because the liver is involved absorption of Vitamin
B12, a diseased or inflamed liver may not be able to keep up with body
demands for this vitamin under stress. B12 is needed to help cells grow
and maintain normal function. It is an especially important vitamin for
healthy bone marrow (where blood cells are formed) and the nervous
system. Not getting enough Vitamin B12 leads to a condition called
pernicious anemia, which results in red blood cells not getting enough
oxygen and causing disorders of the nervous system.
Supplementation with folic acid along with vitamin
B12 has shown promise in helping to reduce the number of days of
hospitalization from viral hepatitis and to speed healing of the injured
liver. Folic acid and vitamin B12 may protect against ribavirin-induced
anemia, which occurs in 10 percent of hepatitis C patients being treated
Biotin is required for fat and protein metabolism,
effective immunity and gene function. Biotin deficiency is most common
in the elderly, people with diabetes and in those who take too many
antibiotics. Anemia, muscle pain, dermatitis and pins-and-needles in the
toes mark biotin deficiency.
Vitamin C provides general support for the immune
system. It also is required for the production of the protein known as
collagen. Collagen found in all tissues of the body. Also found in the
filtration apparatus of the kidneys, which can be diseased in hepatitis
patients. High doses of vitamin C (greater than 2,000 mgs per day) can
cause increased absorption of iron from the bowel and is thus
contraindicated in people with high levels of iron in their liver cells,
which are common in chronic hepatitis patients. High iron level is being
considered to have negative effects on the healing of the liver.
People with hepatitis are often deficient in Vitamin
E, and this deficiency will weaken the immune system, weaken the red
blood cells, and worsen the nerve and muscle damage that can occur with
hepatitis. Vitamin E is a powerful antioxidant. It helps overcome
fatigue and enhances cell mediated immunity. Vitamin E deficiency is
linked to cirrhosis. Vitamin E may prevent some of the molecular changes
associated with the development of cirrhosis.
Vitamin K deficiency is associated with liver
disease. Poor blood clotting is a symptom of deficiency. Vitamin K is a
key cofactor for the formation of a number of proteins that include -carboxyglutamic
acid. The best recognized of these is prothrombin. However, it is now
recognized that carboxylation
is an important enzymatic step for the activation of a wide range of
proteins with many different functions. These proteins are in the blood,
kidney, lung, and bone. It has been recently recognized that vitamin K
plays a role in bone formation. Recent evidence suggests that even
patients with cirrhosis may have abnormal bone turnover and increased
risk of osteoporosis. Vitamin K therapy may improve bone mass among
people with cirrhosis. The role of vitamin K supplementation is of
greatest interest in patients with cholestatic (blockage of bile
secretion) liver disease, both because these patients are at greatest
risk for malabsorption of fat-soluble vitamins and vitamin K is
Chronic liver disease is frequently associated with
osteopenia and osteoporosis and, occasionally, osteomalacia,
particularly in the setting of alcoholic and cholestatic liver disease.
Recent studies suggest that even patients with chronic viral hepatitis
have decreased bone mineral density (BMD) and osteoporosis. Bone disease
associated with cirrhosis is multifactorial in nature and may be due to
malabsorption of fat-soluble vitamins, including vitamin D, and calcium;
malnutrition; and increased bone turnover from hormonal and metabolic
factors. In addition to the nonspecific effects related to chronic liver
disease, patients with cholestatic liver disease are at risk for
malabsorption of calcium and fat-soluble vitamins such as A, D, E, and
K, which may lead to osteomalacia.
Calcium is needed to boost the defense mechanism of
white cells and along with other minerals such as zinc, copper and
manganese for optimizing bone density.
Magnesium is a cofactor involved in a multitude of
metabolic reactions. It levels can be depressed in digestion is poor as
well as in people who exhibit type A behavior.
Manganese is needed of healthy bones and white cell
defense mechanisms. It also may help to reduce the muscle weakness that
is commonly associated with hepatitis.
Selenium is important in a number of immune functions
that help the body’s ability to handle the hepatitis virus. It works
synergistically with glutathione in order to maintain healthy immunity.
It prevents fat oxidation, which reduces the workload of the liver. It
also works with iodine to support healthy thyroid function and is useful
since some hepatitis patients experience thyroid problems.
Zinc is important for bone strength. It also is a
cofactor involved in many metabolic reactions and helps to maintain a
healthy immune system.
Iodine supports healthy thyroid function and may be
helpful since some hepatitis patients experience thyroid problems,
Inositol aids in cholesterol levels of blood, promote
even distribution of fats around the body, combine with other
ingredients in the liver to produce lecithin and also cleanse the blood
of excessive fats, which can reduce the risk of fatty liver.
L-glutathione, abbreviated as "GSH", is the
body’s key antioxidant and protectant. GSH has multiple functions in
disease prevention and in detoxification of chemicals and drugs while
its depletion is associated with increased risks of toxicity and
disease. GSH works synergistically with the other cellular antioxidants
to neutralize and scavenge oxygen and other free radical species and
thereby prevent or diminish "oxidative stress". A deficiency
of hepatic GSH and its antioxidant partners and/or an increase in toxic
free radical species may contribute to the progression of liver disease.
alpha-lipoic acid is an antioxidant that increases production of
glutathione, which helps dissolve toxic buildup in the liver so it can be
flushed out through the kidneys. It also helps make vitamins C and E work
better, and it speeds up the body's metabolism. ALA is a liver cell
membrane stabilizer and can protect the liver cell from the injuries
caused by multiple factors.
Para-aminobenzoic acid (PABA) is an important
antioxidant and a component of folic acid. It stimulates intestinal
bacteria, enabling them to produce folic acid, which aids in production of
pantothenic acid. PABA is necessary for the metabolism of amino acids
and in the formation of blood. Its deficiency is associated with
depression, fatigue and indigestion.
Along with proper treatment, the specific combination
of these vitamins and minerals will help ensure the long-term health of
patients with chronic liver disease.