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Herbs

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Formula List
AI # 3 Capsule
Allicin Capsule
Artemisia Capsule
Artemisia 2 Capsule
(Double Potency)
BM Capsule
Capillaris Combination
Circulation P Capsule
Copmine Formula
Coptis Capsule
Cordyceps Capsule
DH-Artemisinin Capsule
Gall Formula 1
Gineseng and Atractylodes Formula
Glycyrrhizin Capsule
GL2
Hepa Formula 1A
Hepa Formula 2
HerbLipido
HerbSom Capsule
HerbZac Capsule
HH Tablets
HH 2 Capsule
(Double Potency)
Ligustrin Capsule
Milk Thistle Plus
MVM Formula
Olivessence Capsule
Puerarin Capsule
R-5081 Capsule
R-OBG Capsule
Schisandra Plus
Sedin
TGP formula
Yunan Paiyao Capsule
 
Sedin Capsules
Recommended Daily Dose:
1 Capsule, 3 Times a Day

(Individual Dosage May Vary. Please Your Consult Health Care Professional)


Original Herb:

This herb's Chinese name is Chuipencao and its botanical name is Sedum sarmentosum Bunge.

Traditional Chinese Medicine Description:

TCM describes it to have a sweet, bland and slightly sour taste, and a cool property. It is attributed with latent-heat-clearing, antipyretic, diuretic, detoxicant and anti-inflammatory actions. Hence, in China, it is a recommended remedy for chronic hepatitis, carbuncle and deep-rooted ulcer.

 

Chemical Composition:

S. sarmentosum mainly contains cyanophoric glycosides, amino acids, flavonoides, triterpenes and phytosterols. The amino acids are mainly l-asparagine, l-aspartic acid, l-a-alanine, l-leucine, l-tyrosine, and l-valine.

 

Phytopharmacology:

1.        Liver Protective Effects:

S. sarmentosum administered to mice at 0.33g (crude herb)/day PO for six days reduced hepatic necrosis due to carbon tetrachloride (CCl4) poisoning [1]. The herb also significantly protected rats from subacute liver damage due to CCl4.  The treatment group showed markedly lower levels of g-globulin and mild liver fibrosis than the control [1,2]. The water-soluble fraction of the dilute ethanol extract markedly decrease ALT and sodium bromsulphalein retention in rats with subacute liver damage [3]. There were data indicating that amino acids were the active principles responsible for reducing ALT, and that although the alkaloids were also active, they did not protect liver from CCl4 induced damage as the amino acids did [4,5]. In experimental acute icteric hepatitis produced by administration of pentobarbital sodium prior to CCl4, the serum bilirubin level in the control group was 1.6mg%, whereas in the treated group, it was 0.5mg% [3].

Pathological changes in mice resembling the autoimmune type of hepatitis were induced using hepatocellular membrane extract of heterogenous animals as antigen. Serum was collected in the 2nd, 5th, and 9th weeks after immunization for counter-immunoelectrophoresis. Examination of the liver slices revealed hyperplasia of Kuppfer's cells, infiltration of neutrophils and monocytes at the portal area, and punctate necrosis, indicating that this herb had no significant effect on the pathological change [3]. Determination of the bile flow in rats by catheterizing the common bile duct did not show any choleretic (facilitating bile secretion) action from this herb. Also, this herb had no significant effect on the weights of the thymus and spleen of mice [3].

2.        Antibacterial Effects:

In vitro, S. sarmentosum injection at concentrations over 1:50 strongly inhibited Staphylococcus albus, and to a lesser extent, Staphylococcus aureus [6]. No bacteriostatic action was exhibited by its components: triterpenes, phytosterols, cyanophoric glycosides, and alkaloids. The distillate injection, containing 2g of the crude herb per ml, was active against Staphylococcus aureus, Staphylococcus albus, Escherichia coli, Salmonella typhi, Pseudomonas aeruginosa, a streptococcus, b streptococcus, Candida albicans, and Shigella flexneri [7].

3.        Toxicity:

The LD50 of the fluid extract of S. sarmentosum in mice was 54.2 g/kg IP. Intragastric administration of the fluid extract to dogs as 30g/kg/day for 8 weeks produced vomiting and diarrhea, but no abnormalities in the blood counting, ALT, bilirubin, urea nitrogen and serum protein, and no distinct pathological changes in the various organs. Based on these findings, and clinical dosages [2], it can be said that S. sarmentosum has a low toxicity.

 

Clinical Studies in China:

1.        Acute and Chronic Hepatitis:

In Shanghai institute of TCM 1000, cases of acute and chronic hepatitis were treated with the tablets prepared from the fresh or dried herb (total daily dose of 250 and 30 grams, respectively) three times daily for 2 weeks. Consequently, ALT was normalized in 73.6%, improved in 14.8% and unchanged in 11.6% [8]. The Jingchui Tablets (each containing about 8 mg of S. sarmentosum glycoside) was used to treat 200 cases of chronic hepatitis at dosage of 9 tablets daily. It normalized the transaminase level of 167 patients (82%) within two weeks but failed to alter significantly other parameters of the liver function (A/G, GGT, etc.) nor did it cause the disappearance of HBAg [2].  This tablet was also used in 54 cases of intractable chronic hepatitis at dose of 90mg glycoside per day for a course of two months. Transaminase examination revealed that the treatment produced marked effects in 47 cases and moderate effects in 7 cases. Thymol turbidity was normalized in 65.2% and zinc turbidity in 37.3%. No significant changes in the post-treatment g-globulin and HBAg measurements were observed. However, the lymphocyte transformation rate, the phagocytic rate and the phagocytic index of macrophages in the treated patients were markedly decreased, suggesting that the effectiveness of this herb is a result of transient suppression of the cellular immunity. Consequently, most patients relapsed six months after discontinuation of the treatment [2]. In another paper, a transient therapeutic effect was achieved with the syrup prepared from this herb and in the treatment of chronic hepatitis, but it was not comparable to that obtained from S. sarmentosum used alone.

2.        In China, besides the use for hepatitis, it has also been used for corneal ulcer, prevention of eye infection after surgery, insect stings, and viper bites.

   

References:

  1. Shanghai Institute of Traditional Chinese Medicine, Scientific Papers (1966-75), Shanghai College of TCM, 1978 (11):90
  2. Shanghai Institute of Scientific and Technological Information, Shanghai Compilation of New Drugs Confirmed in 1976. Shanghai Sci-Tech Literature Publishing House, 1977. P. 127
  3. Li XY, Abstracts of the First National Symposium of the Society of Pharmacology (China), 1979, p.59
  4. Scientific Information Unite, Ministry of Petrochemical Industry, Developments in Chinese Traditional Drugs (Hunan Institute of Medical and Pharmaceutical Industry) 1977 (8):4
  5. Pathology Department, 178th Hospital of the Chinese PLA. Compiled Information on Clinical Pathology. Coordinating Research Group on Pathology of Fuzhou Military Region. 1977, p.80
  6. Wu GJ, New Chinese Medicine 1975 (3):145
  7. Wu GJ, Wuhu Yiyao (Wuhu Medical Journal) 1978 (2):64
  8. Shanghai Institute of TCM et al., Medical Exchanges (Chinese Medical Association, Shanghai Branch) 1973 (7):27
  9. Lin YY, New Chinese Medicine 1974 5(7):324