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Articles by
Dr. Zhang
 
TCM and MCM Theory Related to Common Liver Disease Blood Test Markers

Low Dose Interferon Patient Experiment

Hepatitis A Prevention Reminder

Hepatitis: Causes of Pain in Liver Region 

The Need to Monitor Your Chronic Hepatitis

Liver Enzyme Fluctuation during Allergy Season 

What are the Serum Markers of Hepatitis B and What do They Mean?

Enterogenous Endotoxemia in Chronic Hepatitis–
Part 2

Enterogenous Endotoxemia in Chronic Hepatitis–
Part 1
 

Chronic Hepatitis and "Blood Activating and Stasis Expelling" (BASE) Therapy -
Part 2

Chronic Hepatitis and "Blood Activating and Stasis Expelling" (BASE) Therapy
Part 1

What Causes Gastrointestinal Bleeding in Cirrhotic Liver Disease

Dietary Support for Cirrhotic Liver Diseases

Ascites - A Complication of De-Compensated Liver Cirrhosis

Liver Cirrhosis - Portal Vein Hypertension Complications

Liver Cirrhosis Overview

PG-IFN and Ribavirin Treatments

Antibiotics and Chronic Liver Diseases

Why is Alcohol Harmful for People with Hepatitis?

Co-infections and Super-infections of Viral Hepatitis

Beware of Medications That Can Cause Liver Damage

Bile Retention and Its Clinical Manifestations (MCM) part 4

Modern Chinese Medicine (MCM) Part 3 
Jaundice and Chronic Viral Hepatitis

Modern Chinese Medicine (MCM) Anti-Liver-Fibrosis Treatments - Part 2

Modern Chinese Medicine (MCM) Anti-Liver-Fibrosis Treatments - Part 1

What is Liver Fibrosis and How is It Different from Cirrhosis?

How does the liver change as we get older?

How is that my LFTs are so good when my viral load is seemly so high?

Comprehensive Care for Chronic Viral Hepatitis

What can Cause Liver Inflammation?  

What Are the Major Functions that the Liver Carries?


 





Part (1)
Modern Chinese Medicine (MCM) Anti-Liver-Fibrosis Treatments

 

Anti-fibrosis has been an important research field in treating chronic liver diseases. "He who can stop or hold the progress of the liver fibrosis, he can cure the chronic liver diseases."

This statement emphasized the paramount importance of anti-fibrosis therapy in treating chronic liver diseases.

Fibrosis is the common pathogenesis of chronic liver diseases. It can happen in chronic viral hepatitis B and C and also in alcoholic, drug, chemical intoxication, and parasitic liver disease. 

Fibrosis is the liver’s repairing reaction to the liver cell injuries and inflammation. Biopsy found that fibrosis exists in 62.6% patients with mild chronic hepatitis and 100% in severe chronic hepatitis (CH). Without proper treatment fibrosis leads CH to cirrhosis, hypertension of portal vein, ascites, hepatic encephalopathy, hepatocellular carcinoma, and even liver failure. However, if this pathological progress can be held, or reversed, the prognosis of chronic liver disease can be greatly changed.

Through many years of studies in animal cirrhotic models, it has been proved that to reverse fibrosis is possible, especially in the early stages of liver disease. The question is, at what stage does fibrosis become irreversible? In order to study this problem, we are badly in need of a non-invasive method to assess the progression of fibrosis and how anti-fibrosis treatment is working. Although many researchers found have found that fibrosis is reversible, it is a common brief that cirrhosis is irreversible.

For more than 40 years, Chinese medical anti-fibrosis studies have also shown that fibrosis can be reversed. Clinically in China, anti-fibrosis with Chinese medicine is a hot spot of research in the treatment of chronic viral hepatitis. With the development of the knowledge of molecular biology of the fibrosis, and integration of Chinese and Western medicine, MCM has developed effective anti-fibrostic treatments.  With these treatments, there is possible to reverse or slow down the progress of the fibrosis and restore the normal liver structure and functions.

The pathophysiological center of the liver fibrosis is the activities of Hepatic Stellate Cells (HSC).

There are three basic phenomena related to liver fibrosis:

1. HSC activation and transferred to be fibroblastic cells
2. Retinoid contained in the HSC reduces
3. The synthesis of Extra Cellular Matrix (ECM) increase and the decomposing of ECM decreases

These are the over-all results of the activation of HSC. The studies on MCM anti-fibrosis treatments were focused on how to suppress the activities of HSC and to interfere the production of related cytokines. Anti-fibrosis therapy is a multi-faces treatment and consists of following aspects:

1.    Controlling the underline primary disease – the chronic viral hepatitis. For other chronic liver diseases, such as alcoholic liver disease, stop drinking, and for parasitic liver disease, eliminate the parasite. Treating the inflammation to prevent liver cell injury. MCM has provided many herbal remedies such as, schizandrin B and C, glycyrrhizin, oleanolic acid, sylimaline, oxymatrine, and Sedum. Most of these herbal remedies can lower the ALT and AST level, protect the intact of the liver cell membrane and reduce the inflammatory cell infiltration and liver cell necrosis.

2.     Suppressing HSC activation and the actions of HSC-related cytokines, such as TGFb1 (transforming growth factor-beta 1), PDGF (platelet delivered growth factor), PAI (Plasminogen activator inhibitor),  and promoting the apoptosis (programmed death) of HSC.

3.        Restore the equilibrium of production and decomposition of ECM. This is the key to reverse the fibrosis. Fibroblastic activity is a dynamic process and theoretically it is reversible. An effective anti-fibrosis treatment should suppress the fiber synthesis and promote its degradation. Chinese herbal treatment can affect both sides. It can suppress the synthesis and secretion of ECM and promoting its decomposition.

Based on many clinical and experimental research works, we have found following Chinese herbs to have anti-fibrostic effects: Salviae Miltiorrhziae Radix Cordyceps sinensis, Persicae Semen, Notoginseng Sanchis Radix, Stephania tetrandra Radix, Cnidii Rhizoma, Angelicae Radix, and Astragali Radix.

These are the components in our anti-fibrosis formulas, through our unique method of extracting the active ingredients for optimum effect.

 

 

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About HCV
Overview
Causes and Transmission

 
Diagnostic Tests
Antibody
HCV RIBA
HCV RNA 
Viral Load

Viral Genotyping

 
Major Signs
Liver Inflammation
Fibrosis
Cirrhosis

 
Peripheral Signs and Symptoms
Fatigue
Jaundice
Bile Retention
Joint Pains and Skin Rashes
Blood Sugar Instability
Portal Vein Hypertension
Ascites

 
Important Liver Function Test Markers
Overview
ALT and AST
ALP and GGT
Albumin
Bilirubin
PT (Prothrombin Time)
 
Liver Biopsy
Overview
Procedure
Inflammation Grade
Fibrosis Stage
 
Interferon Based Treatment
Overview
Ideal Candidate
Possible Side-effects
 
Liver Support with TCM
Overview
Liver Enzymes
Serum Albumin
Blood Clotting Factors
Bile metabolism
GGT
 
Dietary Considerations
Overview
Proteins
Essential Fats
Carbohydrates
Vitamins
 
 

 


 

 

Medical Information Sources:
http://www.nih.gov/
http://www.nlm.nih.gov/

http://nccam.nih.gov/
http://www.medlineplus.org/


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