Medicine Anti-Liver-Fibrosis Treatments (2)
Most MCM anti-fibrosis studies were done in chronic hepatitis B and
schistosomiasis. In MCM's terminology, the main pathogenesis of liver
fibrosis is termed as "blood stasis" and the main treatment method for it
is called "blood activating and stasis expelling".
The interpretation of this treatment principle is to improve the liquidity
of the blood, to reduce its viscosity, to reduce the clustering of red
blood cells and platelets, and to promote the phagocytosis of the
macrophage and removal of circulatory immune complex.
The main traditional formula used is called
"Xue Fu Zhu Yu Tang." Chinese
studies found that in taking "Xue Fu Zhu Yu Tang" formula for
three months, patients' fibrosis markers, such as HA (hyaluronic acid), LN
(Laminin), CIV(collagen IV), PCIII (procollagen type III) levels reduce
Recent studies on the
active ingredients of herbal anti-fibrosis remedies have found many
effective compounds. Some of these active anti-fibrosis ingredients are
listed in following:
1. Cordyceps sinensis (Cs), observed in rat CCl4
fibrostic model, the Cs treated group have a lighter inflammation, fatty
degeneration and less liver cell damage. From the observation of ALT, HA,
LN in liver tissue, found Cs has strong effects on improving regeneration
of hepatocytes and suppression of fibroblasts and collagen fibers.
2. Glycyrrhizin, an active ingredient of Glycyrrhiza uralensis Fisch (Licorice root).
It can reduce the level of ALT, AST, fatty deposit
(steatosis), and fibrosis. Shown in rats models, it can obviously suppress
type I and III pro-collagen synthesis.
Reduce the over active fibrosis-related cytokines in the liver
cell. It has definite liver cell protective effects. T
3. Danshensuan A, is a water soluble ingredient of Salvia miltiorrhiza Bge.
excellent anti-oxidant effects. Animal experiments found that it has
obvious effects to suppress the proliferation of fibroblastic cells and
the synthesis of intracellular collagen.
4. Extract IH764-3 of Salvia
It can obviously reduce the fibrosis in rat
fibrostic models. Obviously reduce the content of
hydrooxyproline (Hyp), type I and III collagen, and HA, LN. Improve
the liver function, and improve the liver histology.
5. Chuanxionyzine, its chemical name is Pyrazine. It is an active
ingredient of Ligusticum chuanziong
Hort. In rat CCl4 fibrostic model, it can reduce ALT, HA, type
III pro-collagen, and obviously reduce the fibrosis. It is also an
anti-oxidant and can increase SOD activities and reduce the level of MDA (methylenedioxyamphetamine).
6. Oxymatrine, it is the extract of Sophorae
Subprostratae Radix. It has anti-viral, anti-inflammatory, and immune
regulatory effects. Recent studies found, it has obvious anti-fibrostic
effects. An obvious fibrosis suppressive effect shown at a concentration
of 62.5 ng/ml. It suppresses the fibroblastic cell activities and
expression of mRNA of type III pro-collagen. The potency of these effects
is concentration dependent. Clinical studies found that the treated group
have lower levels of ALT, CIV, HA, and TNF-b,
and less inflammatory activities and fibrosis than that of the control
7. Extracts of Persicae Semen,
Studies done at Shanghai TCM University found that it can promote the
action of collagen enzyme, reduce type III pre-collagen and increase the
metabolite of collagen, hydroxyproline level in the blood. This substance
has been successfully used to treat cirrhosis caused by viral hepatitis
and parasitic hepatitis.
8. Taurine, it is an active ingredient of nature calculus Bovis. In
TCM, the gallstone of Bos Taurus
demesticus, used to remove heat from the heart, induce resuscitation,
eliminate phlegm, relieve convulsion and remove heat and toxic substance.
Recent studies found that it can suppress HA and the expression of mRNA of
type I and III Pro-collagens. It
can also increase the content of cAMP in the plasma of the cells. In rats
fibrostic model made by continuous injection of bovine albumin, found that
treated with this substance, the collagen deposit in the liver tissue
greatly reduced and the content of Hyp in the liver obviously reduced. In
rat CCl4 fibrostic model, it can obviously reduce the contents
of Hyp, type I and III pro-collagen, HA, LN and improve the liver function
and improve the liver histology.
9. Fustin, an active ingredient of Gleditsia
sinensis Lam. It can obviously suppress the activities of PDGF PDGF
(platelet delivered growth factor) and TGF-b(transforming
growth factor-beta 1). PDGF induces the proliferation of the HSC (Hepatic
Stellate Cells) and promote the activities of TGF-b
which increases collagen and EMC (Extra Cellular Matrix) synthesis. This
substance suppresses PDGF, so it can suppress fibrosis in two phases.