Liver cirrhosis is developed from
fibrosis. Although, fibrosis and
cirrhosis are not exactly the same,
they are closely related.
At the fibrosis stages, the amount
of collagen deposits in the liver
increases and the ratio of
fibro-connective tissue verses liver
cellular tissue increases. But at
this stage, the liver lobular
structures are intact. There is no
Cirrhosis consists of two
fibro-connective tissue hypertrophy
and pseudo-lobule formation. At the
cirrhosis stage, the liver's
fundamental structure is compromised
and deformed, and the framework of
the liver begins collapse. Thus,
reversal is much more difficult.
Right now a liver biopsy is the most
accurate way to diagnose the
fibrosis stages. Some blood chemical
measurements can also provide a
referential diagnostic marker of
fibrosis. The chemical markers that
can be used to assess the fibrostic
activities are: HA (hyaluronic
acid), LN (Laminin), CIV(collagen
IV), PCIII (procollagen type III)
etc. They can show the activities of
fibrosis, but can't classify stages
There are newly developed types of
blood tests such as
Fibrotest used to assess liver
fibrosis activity. However, the
accuracy has not quite matched the
traditional liver biopsy as of yet.
Patients should also understand that
80% to 85% of chronic hepatitis
cases will not lead to cirrhosis.
Only a very small percentage does
and it happens usually without
proper treatment, allowing fibrosis
to go on for years.
The body has amazing healing
capabilities of its own and the
liver is one of the most
“re-generable” organs in the body.
Because fibrosis is the result of
the inflammation, halting or
reversing fibrosis by controlling
inflammation is the key.